颅内静脉窦血栓继发脑实质损伤的相关危险因素分析并文献复习

发布时间：2018-06-04 13:24

本文选题：颅内静脉窦血栓 + 静脉性出血/梗死　；参考：《福建医科大学》2014年硕士论文

【摘要】：目的：探讨颅内静脉窦血栓患者继发脑实质损伤（包括静脉梗死或出血，，脑水肿等）可能存在的相关风险因素（如血栓在静脉窦中的范围和位置，年龄，性别，起病至接受治疗时间，病因），比较两组患者临床症状及预后差异。方法：回顾性分析2009年12月至2014年1月于福建医科大学附属第一医院住院治疗的颅内静脉窦血栓的患者，经颅脑MRI或CT证实，分为A组（未发现脑实质损害），B组（存在脑实质损害，表现为静脉性出血、梗死或脑水肿等）组。收集患者的临床资料、实验室检查及影像学资料，采用CVST评分量化静脉窦中血栓分布及范围，同时分别分析两组患者之间的年龄、性别、病因、起病至治疗时间是否与脑实质损伤存在关联。结果：共入选患者54例，A组患者有27例，B组27例。A组（无脑实质损害）CVST计分平均值：2.51，相对于B组（存在脑实质损伤）CVST计分平均值：4.33，两组比较有统计学意义（P0.05）.；A组患者起病时间166.07±382.32天，B组患者8.44±7.35天，两组比较有统计学意义。而患者年龄、性别及病因分析，无统计学意义，并无证据说明可能对脑实质损伤造成影响。结论：CVST患者中，广泛的静脉窦内血栓形成，急性起病者更容易出现脑实质损伤。相对于无脑实质损伤组患者，脑实质损伤组往往临床症状重。
[Abstract]:Objective: to investigate the possible risk factors associated with cerebral parenchymal injury (including venous infarction or hemorrhage, cerebral edema, etc.) in patients with intracranial venous sinus thrombosis, such as the extent and location of thrombosis in the venous sinus, age, sex, etc. The clinical symptoms and prognosis were compared between the two groups. Methods: the patients with intracranial venous sinus thrombosis treated in the first affiliated Hospital of Fujian Medical University from December 2009 to January 2014 were retrospectively analyzed and confirmed by MRI or CT. Group A (no cerebral parenchymal lesion was found) group B (with cerebral parenchyma lesion, including venous hemorrhage, infarction or cerebral edema, etc.). The clinical data, laboratory examination and imaging data of the patients were collected, and the distribution and extent of venous sinus thrombosis were quantified by CVST score. The age, sex and etiology of the two groups were analyzed respectively. Whether the time from onset to treatment is associated with brain parenchymal injury. Results: a total of 54 patients were enrolled in group A, 27 patients in group B, 27 patients in group A. (average score of CVST without brain parenchyma damage: 2.51), compared with group B (CVST score with cerebral parenchyma injury: average: 4.33), there was significant difference between the two groups (P 0.05). The onset time was 166.07 卤382.32 days in group B and 8.44 卤7.35 days in group B. There was statistical significance between the two groups. Age, sex and etiological analysis were not statistically significant, and there was no evidence of possible effects on brain parenchyma injury. Conclusion among the patients with CVST, extensive venous sinus thrombosis is found, and cerebral parenchymal injury is more likely to occur in patients with acute onset of CVST. Compared with the anencephalic injury group, the cerebral parenchymal injury group often has severe clinical symptoms.
【学位授予单位】：福建医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R743.3

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