依达拉奉联合奥扎格雷对急性脑梗死患者脑血流指标及颈动脉粥样斑块的影响

发布时间：2018-06-05 08:07

本文选题：依达拉奉 + 奥扎格雷　；参考：《中国老年学杂志》2017年12期

【摘要】：目的探讨依达拉奉联合奥扎格雷对急性脑梗死患者脑血流指标以及颈动脉粥样斑块的影响。方法急性脑梗死患者120例,根据随机数字表分为对照组和观察组各60例。对照组给予疏血通,依达拉奉、瑞舒伐他汀钙、阿司匹林进行治疗,观察组在对照组基础上给予奥扎格雷进行治疗。评估两组临床疗效、神经功能缺损、日常生活能力、脑血流指标以及颈动脉粥样斑块等指标。结果观察组总有效率显著高于对照组(χ2=8.010,P0.05)。治疗后,观察组美国国立卫生研究院卒中量表(NIHSS)评分显著低于对照组,日常生活能力量表指数(BI)显著高于对照组(均P0.05)。治疗后观察组收缩期血流速度(Vs)、平均血流速度(Vm)显著高于对照组,阻力指数(RI)和脉动指数(PI)均显著低于对照组(均P0.05)。治疗后观察组颈动脉内膜中层厚度和斑块面积均显著低于对照组(P0.05)。结论依达拉奉和奥扎格雷联合应用能够恢复脑组织血液循环,减小颈动脉粥样斑块,显著提高临床对急性脑梗死的治疗效果,具有较高的临床应用价值。
[Abstract]:Objective to investigate the effects of Edaravone combined with ozagrel on cerebral blood flow and carotid atherosclerotic plaque in patients with acute cerebral infarction. Methods 120 patients with acute cerebral infarction were randomly divided into control group (n = 60) and observation group (n = 60). The control group was treated with Shuxuetong, Edaravone, rosuvastatin calcium and aspirin, and the observation group was treated with ozagrel on the basis of the control group. The clinical efficacy, neurological deficit, ADL, cerebral blood flow and carotid atherosclerotic plaque were evaluated. Results the total effective rate in the observation group was significantly higher than that in the control group (蠂 ~ 2 = 8.010, P 0.05). After treatment, the NIHSS score of the National Institutes of Health in the observation group was significantly lower than that in the control group, and the activity of daily living (ADL) index was significantly higher in the observation group than in the control group (all P 0.05). After treatment, the systolic blood flow velocity and mean blood flow velocity in the observation group were significantly higher than those in the control group, and the resistance index (RI) and pulsatile index (Pi) were significantly lower than those in the control group (all P 0.05). After treatment, the carotid intima-media thickness and plaque area in the observation group were significantly lower than those in the control group (P 0.05). Conclusion the combination of Edaravone and ozagrel can restore blood circulation of brain tissue, reduce carotid atherosclerotic plaque, and improve the clinical therapeutic effect of acute cerebral infarction.
【作者单位】：潍坊市脑科医院;淄博市中心医院ICU;
【分类号】：R743.33

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