吉兰-巴雷综合征的研究进展

发布时间：2018-06-08 11:42

本文选题：吉兰-巴雷综合征 + 流行病学　；参考：《现代生物医学进展》2016年12期

【摘要】：吉兰-巴雷综合征是一种由于感染等原因所致的自身免疫性多发性神经疾病,主要的感染菌为空肠弯曲杆菌。男性患者多于女性。目前临床较为支持的发病机制为分子模拟理论,临床最主要的两大分类是轴索型及脱髓鞘型。欧美等国家以脱髓鞘型为主,亚洲国家以轴索型为主。另外还有一些在吉兰-巴雷综合征中所占比例较低的临床特殊分型,如:Miller Fisher综合征和咽-颈-臂变异型。吉兰-巴雷综合征最有效的治疗方法为静滴丙种球蛋白与血浆置换,且这两种方法的有效性已有循证医学证据支持。激素治疗目前循证医学证据提示无效,基础支持疗法不可轻视。大部分吉兰-巴雷综合征患者为单相病程,仅极少部分患者可复发。Miller Fisher综合征临床预后较好,高龄、轴索型等预后较差。
[Abstract]:Guillain-Barre syndrome is an autoimmune polyneuropathy caused by infection. The main infection bacteria is Campylobacter jejuni. Men have more patients than women. At present, molecular simulation theory is used to support the pathogenesis. The two main clinical classifications are axonal type and demyelinating type. Europe and the United States and other countries to demyelinating the main type, Asian countries to axonal type. There are also some special clinical types that account for a low proportion of Guillain-Barre syndrome, such as: Miller's syndrome and pharynx-neck-arm variant. The most effective treatment for Guillain-Barre syndrome is intravenous immunoglobulin and plasma exchange, and the effectiveness of these two methods has been supported by evidence-based medical evidence. The current evidence of evidence-based medicine suggests that hormone therapy is ineffective and basic support therapy should not be taken lightly. Most of the patients with Guillain-Barre syndrome were monophasic, and only a few of them could recur. Miller Fisher syndrome had a better clinical prognosis, but the old age and axonal type had a poor prognosis.
【作者单位】：第四军医大学西京医院神经内科;杨凌示范区医院;
【基金】：陕西省科技攻关基金项目(2011k14-07-02)
【分类号】：R745.43

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