DWI评价成胶质细胞瘤放化疗后患者生存情况的应用价值

发布时间：2018-06-10 01:41

  本文选题：神经胶质瘤 + 放射疗法　； 参考：《肿瘤》2017年05期

【摘要】：目的:探讨弥散加权成像(diffusion-weighted imaging,DWI)在预测成胶质细胞瘤(glioblastoma,GBM)患者放化疗预后中的价值。方法:对GBM肉眼全切患者进行前瞻性研究。所有患者均接受标准放化疗。术后放疗前进行DWI检查,测量近瘤周区、中瘤周区和远瘤周区的表观弥散系数(apparent diffusion coefficient,ADC)值,分别按ADC平均值和ADC最小值的中位值进行分组,分析患者的总生存(overall survival,OS)和无进展生存(progression-free survival,PFS)情况。结果:共83例患者入组,6个月和12个月的OS率分别为99%和82%,6个月和12个月的PFS率分别为84%和66%。近瘤周区ADC平均值0.979×10-3 mm2/s组的OS和PFS均长于ADC平均值≤0.979×10-3 mm2/s(P OS=0.019,P PFS=0.005);该区ADC最小值0.894×10-3 mm2/s组的PFS长于ADC最小值≤0.894×10-3 mm2/s组(P=0.018)。在中瘤周区和远瘤周区,各组OS和PFS间的差异均无统计学意义(P值均0.05)。结论:DWI对预测GBM患者的放化疗疗效有一定价值。
[Abstract]:Objective: to investigate the value of diffusion-weighted imaging (DWI) in predicting the prognosis of glioblastoma GBM (glioblastomaGBM) patients. Methods: a prospective study was carried out on patients with GBM gross ophthalmectomy. All patients received standard radiotherapy and chemotherapy. DWI was performed before radiotherapy, and the apparent diffusion coefficients (ADCs) were measured in the peri-neoplastic area, the middle peri-tumour area and the paratumoral area. The ADCs were grouped according to the mean value of ADC and the median value of the minimum value of ADCs, respectively, according to the mean value of ADC and the median value of the minimum value of ADC. The total survival rate (OS) and progression-free survival (PFS) were analyzed. Results: the OS rates were 99% and 82% for 6 months and 12 months, and 84% and 66% for 6 months and 12 months, respectively. The mean values of 0.979 脳 10 ~ (-3) mm2/s and 0.894 脳 10 ~ (-3) mm2/s were longer than those in the ADC 鈮，

本文编号：2001536