癫痫患者的认知功能障碍及其影响因素的分析

发布时间：2018-06-10 20:06

本文选题：癫痫认知功能障碍美国同 + MCCB　；参考：《昆明医科大学》2014年硕士论文

【摘要】：目的应用邹义壮2006年引进美国MCCB凸理测量学量表而形成的认知功能量表中文版初步探讨成年癫痫患者的认知功能障碍特点、影响成年癫痫患者认知障碍的各相关因素。方法依据设定的癫痫病例组和健康对照组的纳入和排除标准,选取2013年06月至2014年02月在昆明医科大学第一附属医院神经内科就诊的癫痫患者,共45例为癫痫病例组,以与癫痫病例组年龄、性别、教育程度相匹配的患者家属、陪护人员、医务人员等健康人群50例为健康对照组。应用由邹义壮2006年引进美国MCCB心理测量学量表而形成的认知功能量表中文版从信息处理速度、注意／警觉性、记忆、执行能力、语言能力等方面评估研究对象的认知情况。计算出每位研究对象的量表总分,每个子项目的得分。采用SPSS for windows18.0统计软件分析所得数据。通过两样本均数比较的t检验分析癫痫病例组和健康对照组的得分的差异是否有统计学意义而得出癫痫患者是否存在认知功能的障碍。按照起病年龄、受教育程度、发作频率、发作类型、病程持续时间、用药种类和发作持续时间等将癫痫病例组进行分组评估,通过组间Spearman相关分析来分析这些因素与量表总分及每个子项目间的相关性。结果1、两样本t检验显示,癫痫患者与健康对照组认知功能比较,在信息处理速度(P0.05)、注意／警觉性(P0.05)、记忆(工作记忆、言语记忆P0.05,视觉记忆P0.01)、执行能力(P0.05)、语言能力(P0.01)方面均有统计学意义。2、Spearman相关分析显示癫痫患者认知功能测试总评分与文化程度、起病年龄和疾病严重程度之间,相关系数有显著统计学意义(P0.01),而与用药数量、发作时间、频率、类型之间存在统计学意义(P0.05) 结论1、癫痫患者存在认知功能障碍,并普遍表现在信息处理速度、注意/警觉性、记忆、执行能力、语言能力方面。2、癫痫患者的认知功能障碍程度与文化程度、起病年龄、病程长短、发作频率、发作持续时间、发作类型及用药数量有关。
[Abstract]:Objective to explore the characteristics of cognitive dysfunction in adult epileptic patients using the Chinese version of MCCB Convexity Measurement scale introduced by Zou Yizhuang in 2006. Methods according to the established criteria for the inclusion and exclusion of epilepsy cases group and healthy control group, From June 2013 to February 2014, 45 epileptic patients in the Department of Neurology, the first affiliated Hospital of Kunming Medical University, were selected. 50 cases of healthy people such as medical personnel were taken as healthy control group. The Chinese version of the MCCB psychometric scale introduced by Zou in 2006 was used to evaluate the cognitive status of the subjects in terms of information processing speed, attention / alertness, memory, executive ability, language ability, and so on. The total score of each research object and the score of each subitem were calculated. The data were analyzed by SPSS for windows18.0 software. The difference of scores between epileptic patients and healthy control group was analyzed by t test of comparing the mean of two samples, and whether there was cognitive impairment in epileptic patients was obtained. According to the onset age, education level, attack frequency, attack type, duration of course, drug use and duration of seizure, the epileptic patients were divided into two groups. Spearman correlation analysis was used to analyze the correlation between these factors and the total score of the scale and each sub-item. Results 1. The t test of two samples showed that the cognitive function of epileptic patients was compared with that of healthy controls. At the rate of information processing, P0.05, attention / alertness, P0.05, memory (working memory, The correlation analysis of speech memory, visual memory, executive ability and language ability showed that the total score of cognitive function test was correlated with the education level, the age of onset and the severity of the disease in epileptic patients. The correlation coefficient was statistically significant (P 0.01), but there was significant difference between the number of drugs, attack time, frequency and type. Conclusion 1. There are cognitive dysfunction in epileptic patients, which is generally manifested in information processing speed, attention / alertness. Memory, executive ability and language ability. The degree of cognitive dysfunction in epileptic patients was related to their education, onset age, duration, frequency, duration, type and quantity of medication.
【学位授予单位】：昆明医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R742.1

【参考文献】