血浆炎性因子变化与进展性脑梗死关联性的研究

发布时间：2018-06-11 09:35

本文选题：血浆 + 炎性因子　；参考：《中风与神经疾病杂志》2016年12期

【摘要】：目的探讨血浆炎性因子与进展性脑梗死之间的相关性。方法选择2013年8月-2015年8月在我科治疗的100例脑梗死患者,根据病情的发展分为两个亚组:稳定型脑梗死组和进展性脑梗死组,检测并比较两组血浆(interleukin-6,IL-6)、(interleukin-8,IL-8)和(tumor necrosis factor-alpha,TNF-α)水平差异;根据病史、体检、无创性检查及脑梗死诊断和分级标准,将进展性脑梗死患者严重度分级为重度、中度和轻度,比较稳定型脑梗死组和进展性脑梗死组两组之间及进展性脑梗死不同等级之间IL-6、IL-8和TNF-α水平。结果与稳定型脑梗死组相比,进展性脑梗死组IL-6、IL-8表达水平明显高,有统计学差异(P0.05);TNF-α表达水平两组无明显差异(P0.05);采用配对四格表的卡方检验(Mc Nemar检验)进行分析,结果显示重度、中度和轻度分组之间,IL-6、IL-8和TNF-α表达水平存在两两差异(P0.05),并随着病情的加重逐步升高。结论血浆炎性因子变化与进展性脑梗死之间存在一定的关联性,炎症反应可能参与了脑梗死进展的病理生理机制。
[Abstract]:Objective to investigate the relationship between plasma inflammatory factors and progressive cerebral infarction. Methods 100 patients with cerebral infarction treated in our department from August 2013 to August 2015 were divided into two subgroups according to the development of the disease: stable cerebral infarction group and progressive cerebral infarction group. The levels of interleukin-8IL-8 and tumor necrosis factor-alpha TNF- 伪 were detected and compared between the two groups. According to the history, physical examination, noninvasive examination and criteria for diagnosis and grading of cerebral infarction, the severity of progressive cerebral infarction was classified as severe, moderate and mild. The levels of IL-6, IL-8 and TNF- 伪 were compared between stable cerebral infarction group and progressive cerebral infarction group. Results compared with the stable cerebral infarction group, the expression of IL-6 and IL-8 in the progressive cerebral infarction group was significantly higher than that in the stable cerebral infarction group, and there was no significant difference in the expression level of TNF- 伪 between the two groups. The results showed that the expression level of IL-6 in the progressive cerebral infarction group was significantly higher than that in the stable cerebral infarction group. The results showed that there was no significant difference in the expression level of TNF- 伪 between the two groups. The expression levels of IL-8 and TNF- 伪 between moderate and mild subgroups were significantly different (P 0.05) and increased gradually with the exacerbation of the disease. Conclusion there is a certain correlation between the changes of plasma inflammatory factors and progressive cerebral infarction. Inflammatory reaction may be involved in the pathophysiological mechanism of cerebral infarction progression.
【作者单位】：六安市第二人民医院神经内科;安徽医科大学第一附属医院神经内科;
【基金】：国家自然科学基金(No.81271444)
【分类号】：R743.33

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