染色体9p21.3多态性与颈动脉斑块和神经功能缺损的相关性探讨

发布时间：2018-06-13 05:31

本文选题：急性脑梗死 + p.多态性　；参考：《中风与神经疾病杂志》2017年04期

【摘要】：目的探讨中国汉族人群急性脑梗死患者染色体9p21.3基因多态性与颈动脉斑块、神经功能缺损的相关性。方法采用回顾性病例对照研究,556例急性缺血性卒中病例(无斑块为对照组231例、单斑块组67例、多斑块组258例),根据美国国立卫生院卒中量表(NIHSS)进行评分,颈动脉超声检测颈动脉斑块。用SPSS19.0软件统计数据。结果斑块组的平均住院天数明显多于无斑块组(P0.05)。颈动脉斑块与入院时的NIHSS评分之间呈正相关(P0.05)。无论是在小于等于65岁还是超过65岁两个年龄段,9p21区带上所有6个SNPs(rs10757278、rs1333049、rs2383206、rs1537378、rs4977574和rs2383207)的等位基因频率分布在无斑块组(对照组)与斑块组均无显著性意义(P0.05)。同时发现颈动脉斑块的存在导致严重神经功能缺损(P0.001;OR=2.29;95%CI=1.54~3.40)。单斑组、多斑组患者对神经功能缺损的影响分别为无斑块组的1.87倍(95%CI,1.02~3.42;P=0.043)和2.42倍(95%CI,1.59-3.66;P0.001),而颈动脉斑块的面积大小与神经功能缺损无明显相关性。结论 6个9p21.3区域SNP位点与颈动脉粥样硬化之间无关联性;急性脑梗死发病期有颈动脉斑块的患者有更严重的神经功能缺损。
[Abstract]:Objective to investigate the association of chromosome 9p21.3 gene polymorphism with carotid plaque and nerve function defect in Chinese Han nationality patients with acute cerebral infarction. Methods A retrospective case-control study was conducted in 556 patients with acute ischemic stroke (231 cases without plaque, 67 cases with single plaque and 258 cases with multiple plaque). Carotid plaque was detected by carotid ultrasound. SPSS 19.0 software was used for statistical data. Results the average hospital stay in plaque group was significantly longer than that in no plaque group (P 0.05). There was a positive correlation between carotid plaque and NIHSS score at admission (P 0.05). The allelic frequencies of all 6 SNPs10757278C rs1333049 rs2383206 rs1537378rs4977574 and rs23877320) were not significant in the control group and the plaque group, both in the control group and the plaque group, regardless of the allele frequency distribution in the two age groups (< 65 years old or over 65 years old). At the same time, it was found that the presence of carotid plaques resulted in severe neurological impairment (P 0.001). The effects of single plaque group and multi-plaque group on nerve function defect were 1.87 times 95 times than that of no plaque group (1.02 卤3.42) and 2.42 times 95% CII 1.59-3.66 P 0.001respectively, but there was no significant correlation between the size of carotid artery plaque and nerve function defect. Conclusion there is no correlation between 6 9p21.3 sites and carotid atherosclerosis, and the patients with carotid plaques in acute cerebral infarction have more severe neurological impairment.
【作者单位】：上海市浦东新区公利医院神经科;上海交通大学附属瑞金医院神经科;
【基金】：上海市浦东新区科技发展基金创新基金(PKJ2013-Y01) 上海市卫生和计划生育委员会科研资金(201540157) 上海市浦东新区卫生系统领先人才培养计划(PWR12014-05) 上海市浦东新区卫生系统重点学科建设资助(PWZx2014-08) 上海市医学重点专科建设计划项目(ZK2015B16) 上海市自然科学基金项目(15ZR1437200) 国家自然科学基金面上项目(81571203)
【分类号】：R743.33

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