同型半胱氨酸与缺血性中风关系的临床研究

发布时间：2018-06-14 18:25

本文选题：同型半胱氨酸 + 缺血性中风　；参考：《苏州大学》2015年硕士论文

【摘要】：目的:通过检测血浆中同型半胱氨酸的水平,探讨同型半胱氨酸与缺血性中风之间的关系,更好的预防和治疗缺血性中风。方法:选取我院神经内科2 0 1 3年5月-2 0 1 4年5月收住的4 2例缺血性中风患者和同期在我院体检中心健康体检的3 9例患者作为研究对象,缺血性中风患者经头颅C T或M R I证实,分别对研究对象进行同型半胱氨酸、血脂等生化检测,统计记录化验结果。对缺血性中风患者应用N I H S S评分量表进行病情评估,N I H S S评分4分为轻度脑梗塞,4-1 5分为中度脑梗塞,1 5分为重度脑梗塞。研究比较缺血性中风组与对照组同型半胱氨酸水平之间的差异,两组患者在年龄、甘油三酯、总胆固醇、低密度脂蛋白、高密度脂蛋白等生化指标之间的差异以及缺血性中风组患者同型半胱氨酸水平在性别之间的差异以及不同严重程度的缺血性中风患者与同型半胱氨酸的水平之间的差异,探讨同型半胱氨酸与缺血性中风之间的关系。结果:1、脑梗塞组血浆同型半胱氨酸水平为1 7.6 9±8.0 2(u m o l/L),对照组血浆同型半胱氨酸水平为6.6 3±2.1 7(u m o l/L),脑梗塞组同型半胱氨酸水平明显高于对照组,两组比较差异具有统计学意义(p0.0 5)。2、将脑梗塞根据性别划分为两组,女性的同型半胱氨酸水平为1 7.6 9±7.6 0 u m o l/L,男性的同型半胱氨酸水平为1 7.8 5±7.8 1 u m o l/L,两组之间差异无统计学意义。3、通过对脑梗塞组和对照组年龄、甘油三脂、胆固醇、低密度脂蛋白和高密度脂蛋白的比较,两组患者在年龄、甘油三脂、总胆固醇、低密度脂蛋白、高密度脂蛋白等指标无明显差异(p0.0 5)。4、将脑梗塞患者分为轻度、中度、重度三组,轻度脑梗塞患者同型半胱氨酸水平为1 2.2±2.8 u m o l/L,中度脑梗塞患者为1 6.3±1.8 u m o l/L,重度脑梗塞患者为2 8.1±6.3 u m o l/L,三组脑梗塞患者同型半胱氨酸水平之间的差异具有统计学意义。结论:1、缺血性中风患者有较高的同型半胱氨酸水平,同型半胱氨酸与缺血性中风的发生密切相关。2、同型半胱氨酸是缺血性中风的独立危险因素。3、同型半胱氨酸与缺血性中风病情的严重程度有关,在性别上无明显差异。
[Abstract]:Aim: to investigate the relationship between homocysteine and ischemic stroke by detecting plasma homocysteine level in order to prevent and treat ischemic stroke. Methods: 42 patients with ischemic stroke who were admitted in our department of neurology from May 2003 to May 2004 and 39 patients who were examined in the same period in the physical examination center of our hospital were selected as the study objects. The patients with ischemic apoplexy were confirmed by head C T or M RI. Homocysteine, lipid and other biochemical tests were performed, and the results were recorded. The patients with ischemic apoplexy were assessed with the N I H S score scale. The scores of N I H S score 4 were mild cerebral infarction 4-15%, moderate cerebral infarction 15% and severe cerebral infarction 15%. The study compared the difference of homocysteine levels between ischemic stroke group and control group in age, triglyceride, total cholesterol, low density lipoprotein. The difference of the biochemical indexes such as high density lipoprotein, the difference of homocysteine level between the patients with ischemic stroke and the difference between the patients with different severity of ischemic stroke and the level of homocysteine. To investigate the relationship between homocysteine and ischemic stroke. Results the plasma homocysteine level in the cerebral infarction group was 17.69 卤8.02 u mol / L, and that in the control group was 6.63 卤2.17 u mol / L respectively. The level of homocysteine in the cerebral infarction group was significantly higher than that in the control group. The difference between the two groups was statistically significant. The cerebral infarction was divided into two groups according to sex. Homocysteine level was 17.69 卤7.60 u m o / L in female and 17.85 卤7.81 u m o / L in male. There was no significant difference between the two groups. There was no significant difference in age, triglyceride, total cholesterol, low density lipoprotein and high density lipoprotein between the two groups. Patients with cerebral infarction were divided into three groups: mild, moderate and severe. The difference of homocysteine levels among mild cerebral infarction patients (1.2.2 卤2.8 u m o / L), moderate cerebral infarction patients (16.3 卤1.8 u m o / L) and severe cerebral infarction patients (28.1 卤6.3 u m o / L). It has statistical significance. ConclusionThe patients with ischemic stroke have high homocysteine level. Homocysteine is an independent risk factor for ischemic stroke. Homocysteine is an independent risk factor for ischemic stroke. Homocysteine is associated with the severity of ischemic stroke, but there is no significant difference in sex.
【学位授予单位】：苏州大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R743.3

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