淋巴细胞亚群和NK细胞与新疆地区维汉民族帕金森病的相关性研究

发布时间：2018-06-14 23:31

本文选题：帕金森病 + T淋巴细胞　；参考：《新疆医科大学》2017年硕士论文

【摘要】：目的:研究新疆地区帕金森病(PD)患者外周血中淋巴细胞亚群及NK细胞数量的变化,为PD发病机制研究提供新的视角。方法:应用流式细胞仪荧光染色法测定33例维吾尔族及汉族PD患者外周血中T淋巴细胞,B淋巴细胞,NK细胞数量,并与20例健康对照组进行比较。同时分析不同民族间,不同用药,不同病程及疾病严重程度与各细胞亚群变化的相关性。结果:帕金森病患者外周血中CD3+,CD4+,CD8+T淋巴细胞较对照组明显下降,但B淋巴细胞较对照组无明显变化,NK细胞较对照组上升。维族患者与汉族患者相比,各淋巴细胞亚群及NK细胞数量无明显变化。采用L-多巴胺或盐酸普拉克索治疗患者各细胞亚群无明显改变,CD3+T淋巴细胞亚群与PD患者年龄、B细胞亚群与PD患者病程相关。结论:PD患者外周血的淋巴细胞及NK细胞比例失调,但维汉民族之间无明显差异。外周血T、B淋巴细胞亚群的变化可能有助于评估PD的病情进展。
[Abstract]:Aim: to study the changes of lymphocyte subsets and NK cells in peripheral blood of PD patients in Xinjiang area, and to provide a new perspective for the pathogenesis of PD. Methods: the number of T lymphocyte B lymphocytes and NK cells in peripheral blood of 33 PD patients of Uygur and Han nationality were determined by flow cytometry fluorescence staining and compared with 20 healthy controls. At the same time, the correlation between different nationalities, different drug use, different course of disease and severity of disease with the change of cell subsets was analyzed. Results: the CD3 T lymphocytes in peripheral blood of Parkinson's disease patients were significantly lower than those in the control group, but the B lymphocytes had no significant change compared with the control group, and the NK cells were higher than those in the control group. The number of lymphocyte subsets and NK cells in Uygur patients was not significantly different from that in Han patients. There was no significant change of CD3 T lymphocyte subsets in patients treated with L- dopamine or Praquisol hydrochloride and age B cell subsets were correlated with the course of disease in PD patients. Conclusion the proportion of lymphocytes and NK cells in the peripheral blood of the patients with 10% PD is disordered, but there is no significant difference between the Uygur and Han nationalities. The changes of T B lymphocyte subsets in peripheral blood may be helpful to assess the progression of PD.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R742.5

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