电针疗法联合康复运动训练治疗脑卒中肢体痉挛大鼠的机制

发布时间：2018-06-15 20:31

本文选题：脑卒中 + 肢体痉挛　；参考：《中国老年学杂志》2017年15期

【摘要】：目的探讨电针联合康复运动对脑卒中模型大鼠肢体痉挛的治疗机制。方法取60只SD大鼠,将造模成功者随机分为电针+康复运动组、电针组、康复运动组及正常组和模型组每组10只。建模成功后第3天开始治疗,康复运动组治疗1次/d,30 min/次;电针组治疗1次/d,30 min/次;电针+康复运动组治疗时先进行康复训练治疗,再进行电针治疗,治疗方法及时间与单独治疗组相同三组均连续治疗1 w。分别于术后1、3、10 d对各组大鼠进行神经功能评定,治疗前后测定肌张力实验结束时,取各组大鼠脊髓颈膨大、腰膨大和脑干,测定大鼠突触结合蛋白Ⅰ表达水平。结果电针+康复运动组治疗后大鼠神经功能分数降低最显著,与单独治疗比较差异有统计学意义(P0.05)。与电针组和康复运动组相比,电针+康复运动组改善模型大鼠肌张力效果更明显(P0.05),各组织中的突触结合蛋白Ⅰ表达增多最明显(P0.05)。结论电针联合康复运动训练治疗对模型大鼠脊髓颈膨大组织、脑干组织及腰膨大组织中的突触结合蛋白Ⅰ表达具有明显的促进作用,这可能是联合疗法改善脑卒中大鼠肢体痉挛神经功能及肌肉功能更优的内在机制之一。
[Abstract]:Objective to explore the therapeutic mechanism of electroacupuncture combined with rehabilitation exercise on limb spasm in stroke rats. Methods 60 SD rats were randomly divided into electroacupuncture rehabilitation exercise group, electroacupuncture group, rehabilitation exercise group, normal group and model group. On the third day after modeling, the rehabilitation exercise group was treated for 30 min/, the electroacupuncture group for 30 min/; the rehabilitation exercise group for the rehabilitation training first, and then the electroacupuncture treatment. The treatment method and time were the same as those in the single treatment group for 1 week. The nerve function of each group was evaluated at 1: 3 and 10 days postoperatively. At the end of the experiment, the spinal cord cervical enlargement, lumbar enlargement and brain stem were taken from each group, and the expression level of synaptic binding protein I was measured. Results the scores of nerve function in the electroacupuncture rehabilitation exercise group were significantly lower than those in the control group (P 0.05). Compared with the electroacupuncture group and the rehabilitation exercise group, the electroacupuncture rehabilitation exercise group improved the muscle tension of the model rats more obviously, and the expression of synaptic binding protein I increased most obviously in each tissue. Conclusion electroacupuncture combined with rehabilitation exercise training can significantly promote the expression of synaptic binding protein I in the cervical enlargement tissue, brain stem tissue and lumbar enlargement tissue of the model rats. This may be one of the internal mechanisms of combined therapy to improve limb spasmodic function and muscle function in stroke rats.
【作者单位】：河南中医药大学第一附属医院康复中心;
【基金】：国家中医临床研究项目(2015ZS102)
【分类号】：R743.3

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