灯盏花素联合长春西汀治疗急性脑梗死的临床观察

发布时间：2018-06-16 03:33

本文选题：灯盏花素 + 长春西汀　；参考：《中国药房》2017年26期

【摘要】：目的:探讨灯盏花素联合长春西汀治疗急性脑梗死的临床疗效及安全性。方法:选取2014年1月-2015年12月我院收治的急性脑梗死患者80例作为研究对象,按照随机数字表法分为对照组和观察组,各40例。对照组患者给予长春西汀注射液20mL+0.9%氯化钠注射液250 mL,ivgtt,qd;观察组患者在对照组基础上间隔2~3 h给予灯盏花素注射液20 mL+5%葡萄糖注射液250 mL,ivgtt,qd。两组患者均治疗2周。观察两组患者的临床疗效,治疗前后的血清和肽素、N端前脑钠肽(NT-pro BNP)、白蛋白钴结合(ACB)值以及欧洲卒中量表(ESS)和功能独立性评定(FIM)评分,并记录不良反应发生情况。结果:观察组患者临床总有效率(90.0%)明显高于对照组(67.5%),差异有统计学意义(P0.05)。治疗前,两组患者血清和肽素、NT-pro BNP、ACB值和ESS、FIM评分比较,差异均无统计学意义(P0.05);治疗后,两组患者血清和肽素和NT-pro BNP水平均明显降低,ACB值、ESS和FIM评分明显升高,且观察组患者改善情况均明显优于对照组,差异均有统计学意义(P0.05)。两组患者治疗过程中未见明显的不良反应发生。结论:灯盏花素联合长春西汀可明显改善急性脑梗死患者的神经功能,临床疗效较好,且安全性较高。
[Abstract]:Objective: to investigate the efficacy and safety of breviscapine combined with vinpocetine in the treatment of acute cerebral infarction. Methods: 80 patients with acute cerebral infarction from January 2014 to December 2015 were randomly divided into control group and observation group with 40 cases each. The patients in the control group were treated with vinpocetine injection 20 mL 0.9% sodium chloride injection 250 mL iv gtttqd.The patients in the observation group were treated with breviscapine injection 20 mL 5% glucose injection 250 mL iv GTT QD at intervals of 2 min 3 h. Both groups were treated for 2 weeks. The clinical efficacy, NT-pro BNPP, albumin cobalt binding (ACBB), ESSs and FIM-scores before and after treatment were observed, and the adverse reactions were recorded. Results: the total clinical effective rate in the observation group was significantly higher than that in the control group (P 0.05). Before treatment, the serum and peptide levels of NT-pro BNPP ACB and ESSFIM were not significantly different between the two groups, and after treatment, the levels of serum and peptide and NT-pro BNP were significantly decreased and the scores of ESS and FIM were significantly increased. The improvement of the patients in the observation group was significantly better than that in the control group, and the difference was statistically significant (P 0.05). No significant adverse reactions occurred during the treatment in both groups. Conclusion: breviscapine combined with vinpocetine can significantly improve the neurological function of patients with acute cerebral infarction.
【作者单位】：海南医学院第一附属医院药剂科;海南医学院第一附属医院心血管科;
【分类号】：R743.33

【相似文献】