脑白质疏松症患者的记忆障碍特点与执行功能相关性分析

发布时间：2018-06-16 13:26

本文选题：脑白质疏松症 + 记忆障碍　；参考：《中华疾病控制杂志》2017年08期

【摘要】：目的研究脑白质疏松症(leukoaraiosis,LA)患者记忆障碍的特点和执行功能,并进一步了解记忆障碍与执行功能的相关性。方法采用听觉词汇学习测验(auditory verbal learning test,AVLT)评价LA患者的记忆障碍特点和Stroop色词测验评估患者执行功能,对46例LA患者和46例年龄及受教育程度相匹配的对照者进行研究。结果 LA组较对照组在AVLT即刻回忆、延迟回忆成绩差异均无统计学意义(均有P0.05),在延迟再认成绩上差异有统计学意义(t=-2.306,P=0.026)。LA组较对照组在Stroop色词测验中卡片C(色字)和干扰效应(stroop interfere effects,SIE)成绩差异均有统计学意义(均有P0.05),而在卡片A(点)和卡片B(字)成绩差异均无统计学意义(均有P0.05)。且LA组延迟再认成绩与SIE呈负相关(r=-0.768,P=0.003),即SIE越明显则延迟再认成绩越差。结论 LA患者的记忆障碍特点是以信息提取的能力下降为主,考虑可能与LA患者执行功能下降导致的注意和抑制能力下降有关。
[Abstract]:Objective to study the characteristics and executive function of memory disorder in patients with leukoaraiosis (Leukoaraiosisla), and to understand the relationship between memory disorder and executive function. Methods the memory impairment and the executive function of patients with LA were evaluated by auditory vocabulary learning test (auditory verbal learning test) and Stroop color word test. 46 patients with LA and 46 controls with matched age and education were studied. Results compared with the control group, the LA group had immediate recall in AVLT. There was no significant difference in the scores of delayed recall (all P 0.05). There were significant differences in the scores of delayed recognition. There were statistical differences between the LA group and the control group in the Stroop color word test, the card C (color character) and the interference effect, stroop interfere effectsSIEs. There was no significant difference in the scores of card A (point) and card B (word) (P 0.05). There was a negative correlation between delayed recognition score and sie in LA group, i.e., the more obvious sie was, the worse the delayed recognition score was. Conclusion the characteristics of LA patients' memory impairment are mainly the ability of information extraction, which may be related to the decrease of attention and inhibition caused by the decline of LA patients' executive function.
【作者单位】：阜阳市人民医院干部老年病科;安徽医科大学第一附属医院神经内科;
【基金】：国家自然科学基金(31300925)
【分类号】：R742

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