重复经颅磁刺激联合丁苯酞对脑卒中后运动功能恢复及血清学指标的影响

发布时间：2018-06-16 19:40

  本文选题：脑卒中 + 丁苯酞　； 参考：《东南大学学报(医学版)》2017年06期

【摘要】：目的:探讨重复经颅磁刺激联合丁苯酞对脑卒中患者运动功能及血清学指标的影响。方法:将167例脑卒中患者随机分为观察组85例和对照组82例。两组均常规补液联合丁苯酞治疗,在此基础上,观察组予重复经颅磁刺激治疗。分别于治疗前和治疗后7、14、28 d对患者行美国国立卫生研究院卒中量表(NIHSS)评分,并于治疗前和治疗28 d后测量运动诱发电位(MEP)潜伏期,计算中枢运动传导时间(CMCT),同时检测两组血清NSE、S100B和GFAP水平。结果:观察组治疗7 d后临床症状明显改善,对照组治疗28 d后症状好转;治疗14、28 d神经功能恢复观察组优于对照组,且治疗后28 d有效率和痊愈率观察组高于对照组;MEP潜伏期和CMCT观察组均较对照组明显缩短(P0.05),血清NSE、S100B和GFAP水平观察组明显低于对照组,差异均有统计学意义(P0.05)。结论:重复经颅磁刺激联合丁苯酞治疗能明显促进脑卒中患者的运动功能恢复,并降低患者血清NSE、S100B和GFAP表达水平。
[Abstract]:Objective: to investigate the effects of repeated transcranial magnetic stimulation (TMS) combined with butyphthalide on motor function and serological parameters in stroke patients. Methods: 167 stroke patients were randomly divided into observation group (n = 85) and control group (n = 82). Both groups were treated with routine fluid resuscitation combined with butyphthalide. On this basis, the observation group was treated with repetitive transcranial magnetic stimulation. The patients were assessed with NIHSS before and 7 days after treatment, and the latency of motor evoked potential (MEP) was measured before treatment and 28 days after treatment. The central motor conduction time (CMCTT) was calculated and the serum levels of NSES100B and GFAP were measured. Results: the clinical symptoms of the observation group were obviously improved after 7 days of treatment, the symptoms of the control group were improved after 28 days of treatment, the nerve function recovery of the observation group was superior to that of the control group at 14 and 28 days. 28 days after treatment, the effective rate and cure rate in the observation group were significantly higher than those in the control group and the CMCT group. The serum NSES100B and GFAP levels in the observation group were significantly lower than those in the control group (P 0.05). Conclusion: repeated transcranial magnetic stimulation combined with butyphthalide can significantly promote motor function recovery and decrease the expression of NSES100B and GFAP in patients with stroke.
【作者单位】： 四川省医学科学院·四川省人民医院骨科;
【分类号】：R743.3
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本文编号：2027878