hs-CRP、Lp-PLA2联合CT血管造影在TIA及轻型脑卒中急性期疾病进展中的预测价值

发布时间：2018-06-18 11:52

本文选题：短暂性脑缺血发作 + 急性缺血性轻型卒中　；参考：《山东医药》2017年41期

【摘要】：目的探讨血管炎性标志物高敏C反应蛋白(hs-CRP)、脂蛋白相关磷脂酶A2(Lp-PLA2)联合CT血管造影(CTA)对TIA及轻型脑卒中急性期疾病进展的预测价值。方法收集226例TIA及轻型脑卒中患者,根据发病7 d内疾病进展情况分为进展组29例与非进展组197例,记录基线资料,进行hs-CRP、Lp-PLA2、头颈部CTA检查,比较两组间的差异性。采用ROC曲线分析hs-CRP、Lp-PLA2、头颈部CTA单独及联合对TIA及轻型卒中急性期病情进展的预测价值。结果进展组高血压、糖尿病比例及血浆hs-CRP、Lp-PLA2水平高于非进展组(P均0.05)。头颈部CTA显示责任动脉为中、重度狭窄或闭塞的患者病情进展比例增高,差异有统计学意义(P0.05)。hs-CRP、Lp-PLA2、头颈部CTA以及hs-CRP、Lp-PLA2联合头颈部CTA预测TIA/轻型卒中急性期疾病进展的ROC曲线下面积分别为0.631、0.749、0.748、0.848,三者联合预测的ROC曲线下面积最大。结论血管炎性标志物hs-CRP、Lp-PLA2联合CTA能较好预测TIA/轻型卒中急性期疾病进展风险。
[Abstract]:Objective to evaluate the prognostic value of vasculitis marker Gao Min C-reactive protein hs-CRP, lipoprotein associated phospholipase A _ 2 (Lp-PLA _ 2) combined with CT angiography in predicting the progression of acute stage of Gao Min and mild stroke. Methods 226 patients with TIA and mild stroke were divided into two groups according to the disease progression within 7 days. The baseline data were recorded and the hs-CRPU Lp-PLA2 and head and neck CTA examination were performed to compare the difference between the two groups. ROC curve was used to analyze the predictive value of hs-CRP Lp-PLA2, head and neck CTA alone and combined in TIA and mild stroke. Results the percentage of hypertension, diabetes mellitus and plasma hs-CRPnP Lp-PLA2 levels in the progressive group were higher than those in the non-progressive group (P 0.05). CTA of head and neck showed moderate or severe stenosis or occlusion of the responsible artery. The difference was statistically significant (P 0.05). The area under the ROC curve of head and neck CTA and hs-CRP Lp-PLA2 combined with head and neck CTA for predicting the progression of TIA / mild acute stroke disease was 0.631U 0.749U 0.7480.8488.The area under the ROC curve was the largest. Conclusion hs-CRPX Lp-PLA2 combined with CTA can predict the risk of acute disease progression in TIA / mild stroke.
【作者单位】：苏州大学附属第一医院;
【分类号】：R743.3

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