α-硫辛酸联合甲钴胺治疗对糖尿病周围神经病变患者震动感觉阈值的影响

发布时间：2018-06-19 05:54

本文选题：α-硫辛酸 + 甲钴胺　；参考：《中国老年学杂志》2017年09期

【摘要】：目的探讨α-硫辛酸联合甲钴胺治疗对糖尿病周围神经病变患者震动感觉阈值(VPT)的影响。方法糖尿病周围神经病变患者100例依据随机数表法分为辛酸钴胺组和甲钴胺组,每组50例,甲钴胺组给予0.5 mg甲钴胺静脉推注治疗,辛酸钴胺组在此基础上给予0.6 gα-硫辛酸+250 ml生理盐水静脉滴注治疗,采用酶联免疫吸附法(ELISA)检测血清中总抗氧化能力(T-AOC)、丙二醛(MDA)、超氧化物歧化酶(SOD)水平,比较所有患者治疗疗效、治疗前后血清T-AOC、MDA、SOD水平和治疗前、治疗后7、15、30 d的VPT水平及不良反应发生情况。结果辛酸钴胺组治疗有效率明显高于甲钴胺组(P0.05),两组治疗过程中均无明显不良反应发生;辛酸钴胺组治疗后血清MDA水平明显低于甲钴胺组,血清TAOC、SOD水平明显高于甲钴胺组(P0.05);辛酸钴胺组治疗后7、15、30 d VPT水平明显低于甲钴胺组(P0.05)。结论α-硫辛酸联合甲钴胺治疗可有效提高糖尿病周围神经病变患者的治疗疗效,改善患者的氧化应激状态和VPT水平,且具有良好的安全性。
[Abstract]:Objective to investigate the effect of 伪-lipoic acid combined with mecobalamin on vibration sensation threshold (VPTT) in patients with diabetic peripheral neuropathy. Methods 100 patients with diabetic peripheral neuropathy were randomly divided into Cobalamin octanoate group (n = 50) and mecobalamin group (n = 50). Mecobalamin group was treated with 0.5 mg mecobalamin intravenously. On this basis, 0.6 g 伪 -lipoic acid 250ml normal saline was given intravenously in the cobalamin octanoate group. Serum total antioxidant capacity (T-AOCN), malondialdehyde (MDA) MDAA and superoxide dismutase (SOD) were measured by enzyme linked immunosorbent assay (Elisa). The effect of treatment, the level of serum T-AOCnMDA-SOD before and after treatment and the level of VPT and the occurrence of adverse reactions before and after treatment were compared. Results the effective rate of cobalamin octanoate group was significantly higher than that of mecobalamin group (P 0.05), and there was no significant adverse reaction in both groups, and the serum MDA level in the Cobalamin octanoate group was significantly lower than that in the mecobalamin group after treatment. The level of serum TAOCU SOD was significantly higher than that of mecobalamin group (P 0.05A), and the level of VPT in Cobalamin octanoate group was significantly lower than that in mecobalamin group (P 0.05). Conclusion 伪 -lipoic acid combined with mecobalamin can effectively improve the therapeutic effect of diabetic peripheral neuropathy patients, improve the oxidative stress state and VPT level of patients, and have good safety.
【作者单位】：长治医学院附属和济医院内分泌科;
【基金】：山西高校科技研究开发项目(No.3012430)
【分类号】：R587.2;R745

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