外周全血细胞计数在儿童神经母细胞瘤预后中的意义

发布时间：2018-06-19 10:09

  本文选题：神经母细胞瘤 + 白细胞计数　； 参考：《南京医科大学学报(自然科学版)》2017年11期

【摘要】：目的:分析儿童神经母细胞瘤(neuroblastma,NB)化学治疗前血常规结果与预后生存,探索其中能提示和判断疾病预后的敏感指标。方法:本院初次确诊NB的63例患儿,同时结合入院化疗前首次血常规结果中的白细胞(white blood cell,WBC)、淋巴细胞绝对值(lymphocyte,LYMPH)、中性粒细胞绝对值(neutrophilic granulocyte,NEUT)、红细胞(red blood cell RBC)、血红蛋白(hemoglobin,HGB)、血小板(platelet,PLT),并行生存情况随访,进行Kaplan-Meier生存分析和COX比例风险模型回归分析。结果:PLT≤200×109/L患儿总体生存率低于PLT200×109/L患儿(P0.05),RBC≤4.0×1012/L患儿总体生存率低于RBC4.0×1012/L患儿(P0.05),HGB≤110 g/L患儿总体生存率低于HGB110 g/L患儿(P0.05)。而WBC、LYMPH、NEUT对预后风险评估意义不明显(P0.05)。K-M生存分析:PLT≤200×109/L、RBC≤4.0×1012/L、HGB≤110 g/L是独立评价NB患儿预后不良的指标(P0.05)。而WBC、LYMPH和NEUT对NB患儿预后生存的判断意义不明显(P0.05)。结论:血常规检测简便易行,化疗前血细胞分析结果对NB患儿初步预后判断有一定意义,结合血常规结果制定化疗方案,对预后改善有一定意义。
[Abstract]:Objective: to analyze the blood routine results and prognosis of neuroblastma in children before chemotherapeutic therapy, and to explore the sensitive indexes which can indicate and judge the prognosis of children with neuroblastoma. Methods: 63 cases of NB were diagnosed in our hospital for the first time. At the same time, combined with the results of the first blood routine before admission to chemotherapy, the white blood cell count, the absolute value of lymphocytes, neutrophil granulocyte neuter, erythrocyte red blood cell blood, hemoglobulin HGB, platelet platelet-PLTT, were followed up. Kaplan-Meier survival analysis and Cox proportional risk model regression analysis were performed. Results the overall survival rate of children with 1% PLT 鈮，

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