宽心合剂对于椎基底动脉成形术后再狭窄的影响

发布时间：2018-06-20 02:24

本文选题：宽心合剂 + 椎基底动脉成形术　；参考：《中华中医药学刊》2017年06期

【摘要】：目的:探讨分析宽心合剂对椎基底动脉成形术后再狭窄的影响。方法:随机选取2014年10月—2015年12月来医院行椎基底动脉成形术的患者72例,并随机分为观察组和对照组,每组36例,术后给予两组患者相同的常规抗血小板治疗,观察组在此基础上口服宽心合剂,术后6个月观察两组患者的再狭窄情况。结果:术后6个月后,患者复查头CTA或DSA,观察组有3例发生再狭窄,而对照组有7例,观察组发生再狭窄的人数显著少于对照组,差异具有统计学意义(P0.05),两组患者经治疗后,TXB2水平均得到增高,术后2月最高,但两组对比无明显差异(P0.05);两组患者术后血浆t PA的活性均高于治疗前,术后1月最高,然后逐渐降低,观察组血浆t PA活性的升高情况较对照组更加明显,时间持续更长,差异具有统计学意义(P0.05)。结论:椎基底动脉成形术患者在常规抗血小板治疗的基础上服用宽心合剂,能够有效抑制再狭窄的情况,值得在临床上推广应用。
[Abstract]:Objective: to investigate the effect of Kuanxin mixture on restenosis after vertebrobasilar arterioplasty. Methods: a total of 72 patients with vertebrobasilar angioplasty from October 2014 to December 2015 were randomly divided into observation group and control group with 36 cases in each group. The two groups were treated with the same routine antiplatelet therapy after operation. On this basis, the observation group took Kuanxin mixture and observed the restenosis in both groups 6 months after operation. Results: after 6 months of operation, 3 cases of restenosis occurred in the observation group and 7 cases in the control group. The number of patients with restenosis in the observation group was significantly lower than that in the control group. The difference was statistically significant (P 0.05). After treatment, the level of TXB2 was increased in both groups, but there was no significant difference between the two groups (P 0.05), the activity of plasma t PA in the two groups was higher than that before treatment, and the highest in 1 month after operation, but there was no significant difference between the two groups. The increase of plasma t-PA activity in the observation group was more obvious than that in the control group, and the time lasted longer. The difference was statistically significant (P 0.05). Conclusion: the patients with vertebrobasilar arterioplasty can effectively inhibit restenosis on the basis of routine antiplatelet therapy, which is worth popularizing in clinic.
【作者单位】：河北医科大学附属唐山工人医院介入科;
【基金】：河北省中医药管理局科研计划项目(2014270)
【分类号】：R743

【相似文献】