维持性血液透析患者不宁腿综合征的临床特点及相关因素

发布时间：2018-06-20 07:41

本文选题：不宁腿综合征 + 血液透析　；参考：《重庆医科大学》2017年硕士论文

【摘要】：目的:探讨维持性血液透析(maintenance hemodialysis,MHD)患者中不宁腿综合征(restless legs syndrome,RLS)的发病特点及相关因素,为该病的防治提供科学依据。方法:调查并收集重庆医科大学附属第一医院血液净化中心MHD患者的一般临床资料及生化指标,根据国际不宁腿综合征研究组2012年公布的诊断标准对患者进行RLS的诊断及病情评分,比较RLS与非RLS患者各指标的差异,并通过Logistic回归分析评估影响MHD患者发生RLS的相关因素。结果:307例MHD患者中有37例合并RLS,发生率12.1%,其中73.0%为轻、中度RLS,21.6%为重度RLS,5.4%为极重度RLS;在RLS患者中83.8%为慢性,16.2%为急性或亚急性。RLS与非RLS两组患者年龄、性别、透析龄、血压、体重指数、原发病构成、尿素清除指数(Kt/V)、日均尿量、烟酒史、血红蛋白、肌酐、尿素、尿酸、血钙、血磷、血镁、血钾、全段甲状旁腺素、前白蛋白、白蛋白和碱性磷酸酶等差异均无统计学意义(P0.05),但RLS组患者日常锻炼频率显著低于非RLS组患者(Z=-4.114,P0.001)。Logistic回归分析显示日常锻炼情况与MHD患者RLS的发生呈显著负相关(B=-2.203,OR=0.111,95%CI:0.033~0.371,P0.001)。结论:RLS是MHD患者的常见并发症,在临床上以慢性和轻、中度RLS为主,长期缺乏规律运动可能是RLS发生的重要危险因素。
[Abstract]:Objective: to investigate the characteristics and related factors of restless legs syndrome in maintenance hemodialysis patients with maintenance hemodialysis (MHD), and to provide scientific basis for the prevention and treatment of the disease. Methods: the general clinical data and biochemical indexes of MHD patients in the blood purification center of the first affiliated Hospital of Chongqing Medical University were investigated and collected. According to the diagnostic criteria published by the international restless leg syndrome research group in 2012, the RLS was diagnosed and evaluated. The differences between RLS and non-RLS were compared, and the related factors affecting the occurrence of RLS in MHD patients were evaluated by logistic regression analysis. Results among 307 MHD patients, 37 cases were associated with RLSs, with an incidence rate of 12.1, of which 73.0% were mild and 21.6% were severe RLSs, 83.8% were chronic RLSs, 16.2% were acute or subacute, and 16.2% were acute or subacute. RLS and non-RLS patients were age, sex, dialysis age, blood pressure, hemodialysis age, blood pressure, Body mass index, primary constitution, urea clearance index KT / V, daily urine volume, history of tobacco and alcohol, hemoglobin, creatinine, urea, uric acid, serum calcium, serum phosphorus, serum magnesium, blood potassium, whole segment parathyroid hormone, prealbumin, There was no significant difference in albumin and alkaline phosphatase, but the frequency of daily exercise in RLS group was significantly lower than that in non-RLS group. Logistic regression analysis showed that there was a significant negative correlation between daily exercise and the occurrence of RLS in MHD patients. Conclusion: RLS is a common complication in MHD patients. Chronic, mild and moderate RLS is the main clinical risk factor for RLS. The long-term lack of regular exercise may be an important risk factor for the occurrence of RLS.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R692.5;R747.9

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