基于中西医临床病症特点的短暂性脑缺血发作的动物模型分析

发布时间：2018-06-21 00:15

本文选题：短暂性脑缺血发作 + 临床病症　；参考：《中国中药杂志》2017年14期

【摘要】：基于短暂性脑缺血发作的中医、西医临床病症特点,对目前现有的短暂性脑缺血发作模型进行总结归纳,通过整理分析短暂性脑缺血发作各个动物模型的优缺点、中西医诊断标准以及临床症状吻合度,进一步提出相应动物模型的评价思路及改进方法。而且还发现短暂性脑缺血发作动物模型虽然造模方法比较多,但不能很好地反映该病的短暂性、可逆性、反复发作性等典型特征,与临床病症特点差异较大,且缺少对该动物模型造模成功与否的合理的量化标准。通过利用现有的单因素动物模型相结合,建立与临床病症相结合的、更接近人类短暂性脑缺血发作典型症状的复合动物模型,复制出能更加吻合临床病症特点的动物模型。建立合理的模型量化标准,体现其中西医病因,完善一套系统完整的模型评价方法,是短暂性脑缺血发作动物模型未来的发展方向。
[Abstract]:Based on the clinical features of TCM and Western medicine, the current models of transient ischemic attack are summarized and summarized. The advantages and disadvantages of each animal model of transient ischemic attack are analyzed. The diagnostic criteria of traditional Chinese and western medicine and the degree of coincidence of clinical symptoms were further proposed to evaluate the corresponding animal models and improve the methods. It was also found that although the animal models of transient ischemic attack were more numerous, they could not well reflect the typical characteristics of the disease, such as transient, reversible and recurrent attack, which were different from the clinical symptoms. There is also a lack of reasonable quantitative criteria for the success of the animal model. By combining the existing single factor animal models, a compound animal model, which is closer to the typical symptoms of human transient ischemic attack, is established in combination with clinical symptoms, and the animal model which can be more consistent with the characteristics of clinical symptoms is established. Establishing a reasonable model quantification standard, embodying the etiology of traditional Chinese and western medicine, and perfecting a set of systematic and complete model evaluation methods are the future development direction of the animal model of transient ischemic attack.
【作者单位】：河南中医药大学;
【基金】：国家“重大新药创制”科技重大专项(2009ZX09103-324) 国家自然科学基金项目(U1204827) 河南省优秀科技创新团队(TCJ2014-391)
【分类号】：R-332;R743.31

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