基于脑机接口的经皮穴位电刺激疗法对缺血性中风恢复期患者上肢运动功能的影响

发布时间：2018-06-21 05:08

本文选题：脑机接口 + 经皮穴位电刺激　；参考：《福建中医药大学》2014年硕士论文

【摘要】：目的：研究基于脑机接口(Brain-Computer Interface, BCI)对手三里、外关进行经皮电刺激(Transcutanclus Electrical Acupoint Stimulation, TEAS)对缺血性中风恢复期患者上肢运动功能的影响及其影响机制。方法：将15例严重上肢运动功能障碍的缺血性中风患者随机分为BCI组(8例)和对照组(7例),两组患者均接受常规的康复治疗及药物治疗,此外BCI组患者接受为期8周,每周3次,每次1-1.5小时基于脑机接口对手三里、外关进行经皮电刺激疗法；治疗组仅对手三里、外关进行经皮电刺激,治疗8周,每周3次,每次20分钟。分别在治疗前后对两组患者的中医证候疗效进行评价；用上肢运动功评定量表(Fugl—Meyer motor assessment, FMA)和上肢动作研究测试(Action Research Arm Test, ARAT)评价其运动功能；用运动想象期间的在线准确率及事件相关去同步事件(Event-Related Desynchronization, ERD)评价其治疗前后患者脑电信号的改变。结果：(1)治疗后,两组患者中医证候疗效比较无显著性差异(P0.05)。(2)治疗后,两组患者FMA和ARAT评分均显著高于治疗前(P0.05), BCI组患者FMA和ARAT评分显著高于对照组(P0.05)。(3)治疗后,对照组患者在线准确率较治疗前无显著性差异(P0.05)；治疗后,BCI组患者在线准确率显著高于治疗前(P0.05), BCI组患者的在线准确率显著高于对照组(P0.05)。(4)治疗后,BCI组患侧中央脑区的ERD程度显著强于治疗前(P0.05),对照组健侧中央脑区的ERD强度显著高于治疗前(P0.05); BCI组患侧中央脑区的ERD强度显著高于对照组(P0.05)。结论：对手三里、外关进行经皮电刺激可改善缺血性中风恢复期患者上肢的运动功能；基于脑机接口的经皮穴位电刺激疗法可促进患者主动参与康复治疗,其对缺血性中风患者的运动功能改善更为显著；其康复机理可能与基于脑机接口的经皮穴位电刺激疗法可增加患侧脑区的激活,优化患者大脑运动功能的重组。
[Abstract]:Objective : To study the influence of brain - computer interface ( BCI ) on the exercise function of upper limb in patients with ischemic stroke and its mechanism by using Transcutanclus Electrical Stimulation ( TEAS ) .

Methods : 15 patients with ischemic stroke with severe upper extremity motor dysfunction were randomly divided into BCI group ( 8 cases ) and control group ( 7 cases ) . Both groups received routine rehabilitation therapy and drug therapy .
The curative effect of TCM syndrome of two groups was evaluated before and after treatment .
The exercise function was evaluated by the Fugl - Meyer motor assessment and the upper limb action research test ( ARAT ) .
To evaluate the changes of EEG signals before and after treatment with the online accuracy rate and event - related Desynchronization in the motion picture .

Results : ( 1 ) After the treatment , there was no significant difference between the two groups ( P0.05 ) . After the treatment , the scores of both Chinese and ARAT in both groups were significantly higher than those in the control group ( P0.05 ) . In the control group , there was no significant difference between the two groups ( P0.05 ) .
After treatment , the online accuracy of the patients in the BCI group was significantly higher than that in the control group ( P0.05 ) .

Conclusion : It can improve the exercise function of the upper limb of patients with ischemic stroke during the recovery period of ischemic stroke .
The percutaneous point electro - stimulation therapy based on the brain - computer interface can promote the active participation of the patient in the rehabilitation therapy , which is more remarkable for the improvement of the exercise function of the ischemic stroke patient ;
The mechanism of rehabilitation may be combined with transcutaneous electrical stimulation therapy based on brain - machine interface , which can increase the activation of the affected - side brain region and optimize the function of brain movement of the patient .
【学位授予单位】：福建中医药大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R743.3

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