血栓通注射液与阿司匹林对急性复发性脑梗死的临床研究

发布时间：2018-06-21 07:47

本文选题：血栓通注射液 + 阿司匹林　；参考：《中国临床药理学杂志》2017年06期

【摘要】：目的观察血栓通注射液与阿司匹林治疗急性复发性脑梗死的临床疗效及其对血管内皮生长因子(VEGF)血清水平的影响。方法 80例急性复发性脑梗死患者分为试验组40例与对照组40例。在常规治疗的基础上,对照组给予阿司匹林100 mg pid,口服;试验组在对照组的基础上给予血栓通注射液500mg,每天1次,静脉滴注,2组均连续治疗14 d。观察2组患者的临床疗效,比较2组患者的血流动力学指标变化情况、血栓调节蛋白(TM)、组织纤溶酶原激活物抑制物(PAI)、组织纤溶酶原激活物(t-PA)及D-二聚体(D-dimer)水平及VEGF水平。结果治疗后,试验组总有效率为92.50%(37/40例),对照组为82.50%(33/40例,P0.05)。治疗后,试验组患者全血高切黏度(5.45±0.78)mPa·s,血浆高切黏度(1.87±1.33)mPa·s,对照组全血高切黏度为(5.91±0.24)mPa·s,血浆高切黏度为(2.20±3.09)mPa·s,差异有统计学意义(P0.05)。治疗后,试验组TM为(35.36±8.14)ng·mL~(-1),PAI为(0.73±0.30)AU·mL~(-1),t-PA为(1.97±0.18)U·mL~(-1),D-二聚体为(0.42±0.28)mg·L~(-1);对照组TM为(39.50±10.25)ng·mL~(-1),t-PA为(1.35±0.14)U·mL~(-1),D-二聚体为(0.43±0.24)mg·L~(-1),2组较治疗前差异有统计学意义(P0.05)。试验组t-PA与对照组比较,差异有统计学意义(P0.05)。试验组治疗3,7,14 d的VEGF水平分别为(320.24±45.63),(436.33±35.84),(398.31±46.60)ng·L~(-1),对照组分别为(370.41±39.52),(542.72±68.00),(352.72±49.80)ng·L~(-1),2组差异有统计学意义(P0.05)。所有患者治疗中均未出现药物不良反应,安全性良好。结论血栓通注射液与阿司匹林治疗急性复发性脑梗死疗效显著,血栓通注射液能够有效改善患者血清VEGF水平。
[Abstract]:Objective To observe the clinical efficacy of Xueshuantong injection and aspirin in the treatment of acute recurrent cerebral infarction and its effect on the serum level of vascular endothelial growth factor (VEGF). Methods 80 cases of acute recurrent cerebral infarction were divided into 40 cases in the experimental group and 40 cases in the control group. On the basis of routine treatment, the control group was given 100 mg PID of aspirin, On the basis of the control group, the experimental group was given Xueshuantong injection 500mg 1 times a day, intravenous drip, and the 2 groups were treated with 14 d. to observe the clinical efficacy of the 2 groups, compared the hemodynamic indexes of the 2 groups, thrombomodulin (TM), tissue plasminogen activator inhibitor (PAI) and tissue plasminogen activator (t-P A) and D- two polymer (D-dimer) level and VEGF level. Results after treatment, the total effective rate was 92.50% (37/40) and 82.50% (33/40, P0.05) in the control group. After treatment, the high shear viscosity (5.45 + 0.78) mPa s, plasma high shear viscosity (1.87 + 1.33) mPa s, and the high shear viscosity (5.91 + 0.24) of the control group were (5.91 + 0.24) mPa. The viscosity was (2.20 + 3.09) mPa s, and the difference was statistically significant (P0.05). After the treatment, the test group was (35.36 + 8.14) ng. ML~ (-1), PAI was (0.73 + 0.30) AU mL~ (-1), t-PA was (1.97 + 0.18) and 0.42 + 0.28); the control group was (39.50 + 10.25). 24) mg. L~ (-1), the difference between the 2 groups was statistically significant (P0.05). The difference between the experimental group t-PA and the control group was statistically significant (P0.05). The VEGF level of the experimental group was (320.24 + 45.63), (436.33 + 35.84), (398.31 + 46.60) ng. L~ (-1), and the control group (370.41 + 39.52), (542.72 + 68), (352.72 + 49.80) ~ (-1), the difference between the 2 groups was statistically significant (P0.05). All patients had no adverse drug reactions and had good safety. Conclusion Xueshuantong injection and aspirin were effective in the treatment of acute recurrent cerebral infarction, and Xueshuantong injection could effectively improve the level of serum VEGF in patients.
【作者单位】：丽水市中心医院神经外科;台州市中心医院神经内科;
【基金】：浙江省医药卫生科技计划基金资助项目(2014KYB312)
【分类号】：R743.33

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