超早期强化降压治疗对脑出血血肿扩大、血浆MMP-9及神经功能的影响

发布时间：2018-06-22 15:01

本文选题：脑出血 + 强化降压　；参考：《中外医疗》2018年02期

【摘要】：目的为了提高脑出血患者的治疗效果,研究和探讨超早期强化降压治疗对脑出血血肿扩大、血浆MMP-9及神经功能的影响。方法从2016年5月—2017年5月来该院治疗的高血压脑出血患者中方便选取100例作为研究对象并通过随机数字表的方法将其进行分组,其中接受常规降压治疗的设为对照组,接受超早期强化降压治疗的设为试验组,比较不同治疗方案对各观察指标的影响。结果研究数据显示,试验组和对照组都取得一定的治疗效果,其中试验组患者治疗后NIHSS评分、血肿体积以及MMP-9分别为(5.5±0.8)分、(12.24±7.02)mL、(102.61±14.25)ng/mL,而对照组患者治疗后NIHSS评分、血肿体积以及MMP-9分别为(8.1±1.2)分、(14.68±6.23)mL、(1 110.34±23.60)ng/mL,和对照组相比试验组患者的各评估指标明显占优势,且比较差异有统计学意义(P0.05)。结论高血压脑出血患者接受超早期强化降压治疗,有利于减少血肿扩大,降低血肿MMP-9水平,促进神经系统功能恢复,效果显著,值得推广。
[Abstract]:Objective to study the effect of intensive hypotension therapy on hematoma enlargement, plasma MMP-9 and nerve function in patients with intracerebral hemorrhage (ICH). Methods from May 2016 to May 2017, 100 patients with hypertensive intracerebral hemorrhage treated in our hospital from May 2016 to May 2017 were selected as study objects and divided into groups by random number table, among which the patients who received conventional hypotension therapy were set up as control group. The patients who received super early intensive hypotension therapy were selected as the experimental group and the effects of different treatment regimens on the observation indexes were compared. Results the data of the study showed that both the experimental group and the control group achieved certain therapeutic effects. The NIHSS scores, hematoma volume and MMP-9 were (5.5 卤0.8), (12.24 卤7.02) mL, (102.61 卤14.25) ng / mL in the experimental group, and (102.61 卤14.25) ng / mL in the control group, respectively, and the NIHSS scores of the patients in the control group after treatment were (5.5 卤0.8), (12.24 卤7.02) mL, (102.61 卤14.25) mg / mL, respectively. The hematoma volume and MMP-9 were (8.1 卤1.2), (14.68 卤6.23) mL, (1 110.34 卤23.60) ng / mL, respectively. Conclusion intensive hypotension therapy in patients with hypertensive intracerebral hemorrhage is beneficial to reduce hematoma enlargement, decrease the level of MMP-9 in hematoma, promote the recovery of nervous system function, and is worth popularizing.
【作者单位】：淄博矿业集团有限责任公司中心医院神经内科;
【分类号】：R743.34

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