丁苯酞对急性脑血栓形成患者血浆溶血磷脂酸水平和临床疗效的影响

发布时间：2018-06-23 01:41

本文选题：溶血磷脂酸(LPA) + 丁苯酞注射液　；参考：《中国老年学杂志》2017年21期

【摘要】：目的观察丁苯酞对急性脑血栓形成患者血浆溶血磷脂酸(LPA)水平及临床疗效的影响。方法急性脑血栓形成患者96例,随机分为添加丁苯酞治疗组(丁苯酞组48例)和不添加丁苯酞治疗组(常规治疗组48例);同时选择门诊体检者为正常对照组(48例)。分别测定入院时和治疗后3 d,7 d,14 d血浆LPA水平,采用美国国立卫生研究所脑卒中量表进行评估临床病情严重程度和治疗效果,治疗前及治疗14 d后采用Barthel指数(BI)、焦虑量表(SAS)和抑郁量表(SDS)等测试。结果两组急性脑血栓形成患者血浆LPA水平均较正常对照组明显增高(P0.01);丁苯酞组和常规治疗组血浆LPA水平在治疗后3 d和7 d逐渐下降,14 d基本降至正常水平,两组治疗后神经功能缺损程度均有改善,日常生活能力均有提高,但丁苯酞组优于常规治疗组(P0.01)。与治疗前及与常规治疗比较,丁苯酞组治疗14 d后SAS、SDS评分明显降低(P0.05)。结论在急性脑血栓形成患者治疗中添加丁苯酞可显著降低血浆LPA水平,降低神经功能缺损评分,提高日常生活能力,减轻焦虑、抑郁症状,有效提高患者生存质量。
[Abstract]:Objective to observe the effect of butyphthalide on plasma lysophosphatidic acid (LPA) level and clinical efficacy in patients with acute cerebral thrombosis. Methods 96 patients with acute cerebral thrombosis were randomly divided into butyphthalide group (n = 48) and control group (n = 48). Plasma LPA levels were measured at admission and at 3 days and 7 days after treatment. The severity of the disease and the therapeutic effect were evaluated by the stroke scale of the National Institutes of Health of the United States of America. Barthel index (BI), anxiety scale (SAS) and depression scale (SDS) were measured before and 14 days after treatment. Results the plasma LPA levels in patients with acute cerebral thrombosis in both groups were significantly higher than those in the control group (P0.01), and the plasma LPA levels in butyphthalide group and routine treatment group were gradually decreased to normal level at day 3 and day 7 after treatment. The degree of nerve function defect was improved and the ability of daily living was improved in both groups. Dante phthalide group was superior to the routine treatment group (P0.01). Compared with before treatment and routine treatment, the SDS score of BPD group decreased significantly after 14 days of treatment (P0.05). Conclusion the addition of butyphthalide in the treatment of patients with acute cerebral thrombosis can significantly reduce the level of plasma LPA, reduce the neurological deficit score, improve the ability of daily life, alleviate the symptoms of anxiety and depression, and effectively improve the quality of life of the patients.
【作者单位】：北华大学附属医院神经内科;吉林大学第一医院超声科;吉林省职业病防治医院;
【基金】：吉林市科技计划项目(201437003)
【分类号】：R743.32

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