脑出血患者血肿和血浆中纤溶活性的相关性研究

发布时间：2018-06-23 19:07

本文选题：脑出血 + 颅内血肿　；参考：《中风与神经疾病杂志》2017年01期

【摘要】：目的通过测定高血压性脑出血患者血肿内及血浆中纤溶酶原、D-二聚体的含量,以探讨颅内血肿纤溶活性及外周血纤溶活性的特点及相关性。方法选择2014年1月~2015年12月在山东省交通医院神经内科住院的行颅内血肿微创穿刺清除术的幕上高血压性脑出血患者20例。同时期选择20例健康查体者作对照组。留取手术组患者血肿及外周静脉血标本及对照组外周静脉血标本,采用酶联免疫吸附试验双抗体夹心法(ELISA)检测上清液纤溶酶原、D-二聚体水平。结果手术组患者外周血及血肿测得纤溶酶原比较,手术组外周血纤溶酶原均值(12.36±3.54)ng/ml,手术组血肿内纤溶酶原均值(14.99±3.70)ng/ml,两组间行独立样本t检验得t=2.293,P=0.0270.05,两组间差异有统计学意义;手术组患者血肿及外周血纤溶酶原相关性检验具有正相关性(R=0.670,P=0.0010.01);手术组患者血肿及外周血测得D-二聚体相关性检验无相关性(R=0.128,P=0.5910.01)。结论高血压性脑出血患者血肿内存在纤溶酶原,血肿内平均纤溶酶原的含量要高于外周血,且两者之间存在相关性。
[Abstract]:Objective to investigate the characteristics and correlation of fibrinolytic activity and peripheral blood fibrinolytic activity in patients with hypertensive intracerebral hemorrhage by measuring the content of plasminogen D dimer in hematoma and plasma. Methods from January 2014 to December 2015, 20 patients with supratentorial hypertensive intracerebral hemorrhage who were hospitalized in Department of Neurology, Shandong Communication Hospital, underwent minimally invasive puncture removal of intracranial hematoma. At the same time, 20 healthy persons were selected as control group. The hematomas and peripheral venous blood samples of the patients in the operation group and the peripheral venous blood samples of the control group were collected and the supernatant plasminogen D dimer levels were detected by enzyme linked immunosorbent assay (Elisa). Results the mean value of plasminogen in peripheral blood and hematoma was (12.36 卤3.54) ng / ml in the operation group and (14.99 卤3.70) ng / ml in the operation group respectively. There was a positive correlation between hematoma and peripheral blood plasminogen in operation group (R0. 670 P0. 0010.01), but there was no correlation between hematoma and peripheral blood in operation group (RV 0. 128 P0. 5910.01). Conclusion there is plasminogen in hematoma in patients with hypertensive intracerebral hemorrhage, and the average content of plasminogen in hematoma is higher than that in peripheral blood, and there is a correlation between them.
【作者单位】：山东省交通医院;
【分类号】：R743.34

【相似文献】