癫痫持续状态联合药物治疗的研究现状

发布时间：2018-06-24 14:04

本文选题：癫痫 + 癫痫发作　；参考：《重庆医科大学》2017年硕士论文

【摘要】：癫痫持续状态(SE)神经科常见的急危重症,其病死率、致残率高,迅速、有效地控制癫痫发作是挽救患者生命、改善预后的关键。目前临床用于治疗SE的传统方案,尽管有60-70%的疗效,但仍有30-40%的癫痫发作不能从目前的治疗中获益。鉴于癫痫持续状态的病因多样,发病机制复杂,联合药物治疗因不同机制产生的协同作用,可能更有利于患者的治疗,在缺乏实验及临床证据证明单药比联合药物治疗更能改善SE患者预后情况下,探索SE的联合应用可能有其潜在的应用价值。本综述的目的是要总结近年来有关动物实验及临床实践中联合药物治疗SE的现状,有助于研究者制定良好的前瞻性治疗协议,寻求更好地治疗SE的方案,以保证早期有效地应用抗癫痫药物终止SE。
[Abstract]:Epileptic status (SE) neurology is a common acute and critical disease. Its mortality and disability rate are high. It is the key to save life and improve prognosis to control seizures quickly and effectively. Despite 60-70% curative effect, 30-40% of epileptic seizures do not benefit from the current treatment. Since the etiology of epileptic status is diverse and the pathogenesis is complex, the synergistic effect of combined drug therapy due to different mechanisms may be more beneficial to the treatment of patients. In the absence of experimental and clinical evidence to prove that single drug therapy can improve the prognosis of patients with SE, exploring the combined use of SE may have its potential application value. The purpose of this review is to summarize the current situation of combined drug therapy in animal experiments and clinical practice in recent years, and to help researchers to formulate a good prospective treatment protocol and to seek a better regimen for the treatment of SE. In order to ensure the early and effective use of antiepileptic drugs to terminate Se.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R742.1

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