临床及亚临床快速眼动睡眠期行为障碍与帕金森病认知功能的相关性

发布时间：2018-06-26 19:43

本文选题：帕金森病 + 快速眼动睡眠期行为障碍　；参考：《实用医学杂志》2017年20期

【摘要】：目的探讨快速眼动睡眠期行为障碍(REM sleep behavior disorder,RBD)及亚临床快速眼动睡眠期行为障碍(subclinical REM sleep behavior disorder,s RBD)与帕金森病(Parkinso's disease,PD)患者认知功能的关系。方法选择南昌大学第二附属医院53例PD患者,记录患者的年龄、性别、学历等一般情况。排除存在痴呆的PD患者,以面对面的方式进行相关量表评估,包括蒙特利尔认知量表评分(Montrealcognitive function score,MoCA)、帕金森病综合评分量表(Unified Parkinson Disease Rating Scale,UPDRS)、帕金森病睡眠量表(Parkinson Disease Sleep Scale,PDSS)等。使用多导睡眠图监测患者的睡眠质量,并进行分组:PD合并RBD组(PD-RBD)、PD合并s RBD组(PD-s RBD)、PD正常组(PD-REM),比较3组之间认知功能的差异。结果 (1)PD-RBD组的MoCA总分较PD-REM组低(P=0.032)。(2)PD-s RBD与PD-REM组的认知功能差异无统计学意义。(3)PD-RBD组病程较PD-s RBD组更长(P=0.021)。结论 RBD可能是PD患者认知功能障碍的一个重要相关因素;s RBD对PD的认知功能无明显相关;尚不清楚s RBD是否会进展为RBD,仍需进一步的研究。
[Abstract]:Objective to investigate the relationship between REM sleep behavior sleep disorder (REM sleep behavior disorder) and subclinical REM sleep behavior disorder (subclinical REM sleep behavior disordersRBD) and cognitive function in patients with Parkinson's disease (PD). Methods 53 patients with PD were selected from the second affiliated Hospital of Nanchang University and their age, sex and educational background were recorded. The PD patients with dementia were excluded and evaluated in a face-to-face manner, including Montreal Cognitive function scoremoca, Unified Parkinson Disease rating scale (UPDRS), Parkinson Disease Sleep scale (PD), and so on. The sleep quality of patients was monitored by polysomnography, and the cognitive function of normal PD group (PD-REM) was compared with that of normal PD group (PD-s RBD) and PD combined with RBD (PD-RBD) group (PD-RBD) and normal PD group (PD-REM). Results (1) the total score of MoCA in PD-RBD group was lower than that in PD-REM group (P0.032). (_ 2) there was no significant difference in cognitive function between PD-s RBD and PD-REM group. (3) the course of disease in PD-RBD group was longer than that in PD-s RBD group (P0. 021). Conclusion RBD may be an important factor related to cognitive dysfunction in PD patients. There is no significant correlation between sRBD and cognitive function of PD, and it is not clear whether sRBD will progress to RBD, which needs further study.
【作者单位】：南昌大学第二附属医院神经内科;安徽省淮南市第一人民医院神经内科;
【基金】：江西省科技支撑计划项目(编号:20151BBG70190)
【分类号】：R742.5

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