活血散瘀醒脑汤对微创血肿清除后脑出血患者血浆MMP-9与神经功能的影响

发布时间：2018-06-30 02:39

  本文选题：脑出血 + MMP-　； 参考：《中华中医药学刊》2017年05期

【摘要】：目的:探讨活血散瘀醒脑汤对微创血肿清除后脑出血患者血浆MMP-9与神经功能的影响。方法:选取医院2013年3月—2015年5月收治的108例脑出血患者作为研究对象,采用随机数字表法分为观察组和对照组,每组各54例。两组患者入院后均给予常规对症治疗及血肿微创清除手术,而观察组患者则在此基础上加以中药活血散瘀醒脑汤治疗,观察患者治疗过程中血浆MMP-9含量及治疗后神经功能缺损情况,并对结果进行比较分析。结果:两组患者MMP-9水平均于术后2 d达到最高峰,治疗7 d后明显降低,其中观察组患者治疗7d和治疗14 d的MMP-9的水平均明显低于对照组(P0.05);治疗14 d后两组NDS均较入院时明显降低,其中观察组明显低于对照组(P0.05),且观察组基本痊愈人数相比对照组明显增加(P0.05),差异均具有统计学意义。结论:活血散瘀醒脑汤能有效降低脑出血患者微创血肿清除术后血浆MMP-9水平,降低其神经功能缺损程度,并因此提高临床治疗效果。
[Abstract]:Objective: to investigate the effect of Huoxue Sanyu Xingnao decoction on plasma MMP-9 and nerve function in patients with intracerebral hemorrhage after minimally invasive hematoma clearance. Methods: 108 patients with intracerebral hemorrhage from March 2013 to May 2015 were selected and randomly divided into observation group and control group with 54 cases in each group. The patients in both groups were treated with routine symptomatic treatment and minimally invasive hematoma removal, while those in the observation group were treated with traditional Chinese medicine Huoxue Sanyu Xingnao decoction. The levels of MMP-9 in plasma and neurological deficit after treatment were observed and compared. Results: the level of MMP-9 in both groups reached its peak on the 2nd day after operation and decreased significantly after 7 days of treatment. The levels of MMP-9 in the observation group were significantly lower than those in the control group on the 7th day and the 14th day after treatment (P0.05), and the levels of NDS in the two groups were significantly lower than those in the control group after 14 days of treatment. The observation group was significantly lower than the control group (P0.05), and the observation group was significantly increased compared with the control group (P0.05), the difference was statistically significant. Conclusion: Huoxue Sanyu Xingnao decoction can effectively reduce the level of MMP-9 in patients with intracerebral hemorrhage after minimally invasive hematoma clearance, reduce the degree of neurological deficit, and improve the clinical therapeutic effect.
【作者单位】： 河南理工大学第一附属医院焦作市第二人民医院;
【基金】：河南省科技攻关重点项目(0323034200)
【分类号】：R743.34
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本文编号：2084488