脑肿瘤患者手术前后脑结构网络拓扑属性研究

发布时间：2018-07-02 14:48

本文选题：弥散张量成像 + 大脑结构网络　；参考：《中国生物医学工程学报》2017年02期

【摘要】：主要研究脑肿瘤的存在及手术对患者全脑及半脑结构网络拓扑属性的影响。结合弥散张量成像技术(DTI)和图论方法,对10例健康志愿者以及10例脑肿瘤患者进行术前术后全脑及半脑结构网络构建,获得两组受试者脑结构网络拓扑属性参数,以及反映脑认知功能的各项网络指标,并对其进行统计对比分析。结果显示,部分局部参数(包括K_i、L_i、E_(nodal)、C_i和E_(ilocal))在手术前后具有明显差异,且术前组均优于术后组;全脑及半脑各全局网络参数显示,各项参数术前组均优于术后组;同时半脑结构网络分析显示,位于不同脑半球的脑肿瘤对患者脑结构网络所造成的损伤均无统计学差异(P0.05)。肿瘤的存在以及手术均使得脑肿瘤患者脑结构网络发生改变,大脑的半脑优势化趋势明显降低;手术后结构网络拓扑特性的改变以及小世界属性的增强,验证大脑本身存在的代偿机制以及功能重组现象。
[Abstract]:The effect of the existence and operation of brain tumor on the topological properties of the whole brain and half brain structure of the patients was studied. Combined with the method of diffusion tensor imaging (DTI) and graph theory, 10 healthy volunteers and 10 patients with brain tumors were constructed before and after operation, and the topological properties of the brain structure network of two groups were obtained. The results showed that some local parameters (including K_i, L_i, E_ (nodal), C_i and E_ (ilocal)) had obvious differences before and after operation, and all the preoperative groups were superior to those of the post operation group, and the parameters of all the whole brain and half brain networks showed that all the parameters of the pre operation group were excellent. At the same time, the analysis of the brain structure network in different hemispheres showed that there was no significant difference in brain structure network damage (P0.05). The existence of the tumor and the operation made the brain structure network of the brain tumor patients changed, the tendency of the cerebral hemispherical dominance decreased obviously; the post operation structure network was significantly reduced. The change of topological properties and the enhancement of small world properties verify the compensatory mechanism and functional reorganization of the brain itself.
【作者单位】：南京航空航天大学自动化学院;
【基金】：国家自然科学基金(61275199) 中央高校基本科研业务费专项(NS2015032)
【分类号】：R739.41

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