肌萎缩侧索硬化患者脑部基于体素的形态学MRI研究

发布时间：2018-07-04 16:52

本文选题：肌萎缩侧索硬化 + 初级运动区　；参考：《南京中医药大学》2014年硕士论文

【摘要】：目的：探讨肌萎缩侧索硬化(Amyotrophic lateral sclerosis, ALS)患者全脑的形态学变化特点。方法：采用3.0T磁共振,研究31例ALS患者及31例性别、年龄相匹配的正常志愿者。运用SPM8分析软件,采用基于体素的形态学测量方法(Voxel-based morphometry, VBM),进行全脑比较分析。并对ALS患者灰质图与修订版ALS功能评分(Revised ALS functional rating scale, ALSFRS-R)、疾病进展率及病程进行相关分析。结果：与正常对照组比较,ALS患者双侧初级运动区、运动前回、辅助运动区及躯体感觉区等运动相关区域灰质体积缩小。此外,两侧额叶、颞叶及枕叶等非运动区皮层也发生萎缩(P0.001, uncorrected, k≥703)。ALS患者右侧运动前回灰质体积与ALSFRS-R评分呈正相关(P0.001,uncorrected, k≥75)。结论：通过VBM分析发现ALS患者是累及多系统的疾病,初级运动区体积的显著缩小,有可能作为识别ALS患者运动区广泛损伤的结构标记物。
[Abstract]:Objective: To investigate the morphological changes of the whole brain in patients with Amyotrophic lateral sclerosis (ALS). Methods: 31 cases of ALS and 31 normal sex and age matched normal volunteers were studied by 3.0T magnetic resonance (3.0T). The morphological measurement based on voxel based morphology (Voxel-based morphometry, V) was used in SPM8 analysis software. BM) comparative analysis of whole brain and correlation analysis of gray matter map of ALS patients with revised version ALS function score (Revised ALS functional rating scale, ALSFRS-R), disease progression rate and course of disease. Results: compared with normal control group, bilateral primary motor area, pre movement gyrus, auxiliary motor area and somatosensory area were related to normal control group. In addition, the cortex of non motor areas, such as the frontal lobes, the temporal lobe and the occipital lobe, also atrophied (P0.001, uncorrected, k > 703) in.ALS patients, there was a positive correlation between the right premotor gyrus volume and the ALSFRS-R score (P0.001, uncorrected, k > 75). Conclusion: the VBM analysis found that the ALS patients were the diseases involving multiple systems, primary A marked reduction in the volume of the motor area may serve as a structural marker for identifying the extensive damage in the motor area of ALS patients.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R744.8

【共引文献】