hs-CRP持续升高与进展性脑梗死的关系研究

发布时间：2018-07-06 20:23

本文选题：超敏C-反应蛋白 + 进展性脑梗死　；参考：《中国现代医学杂志》2017年29期

【摘要】：目的探讨超敏C-反应蛋白(hs-CRP)持续升高与进展性脑梗死的关系。方法选取2014年1月-2016年3月贵州省黔西南州人民医院收治的136例急性脑梗死患者作为研究对象,根据其入院时、发病48和72 h后的hs-CRP水平分为持续升高组和非持续升高组,并根据是否发生进展性脑梗死分为进展组和非进展组,比较各组的基线资料、临床指标、入院时的美国国立卫生院神经功能缺损评分(NHISS)、发热、颈动脉狭窄等临床资料。采用Logistics回归分析,筛选出患者出现hs-CRP持续升高及进展性脑梗死的影响因素。结果全部患者中,36.8%(50/136)出现进展性脑梗死,34.6%(47/136)出现hs-CRP持续升高。进展组患者hs-CRP持续升高的发生率为54.0%(27/50),高于非进展组的23.3%(20/86)(P0.05)。多因素Logistic回归分析结果表明,糖尿病史、三酰甘油、血白细胞计数是患者出现hs-CRP持续升高的影响因素(P0.05)。空腹血糖、入院时的NHISS评分、发热、hs-CRP持续升高是患者出现进展性脑梗死的影响因素(P0.05)。结论进展性脑梗死与hs-CRP持续升高有关,进展性脑梗死患者的血清hs-CRP水平升高。
[Abstract]:Objective to investigate the relationship between continuous elevation of high-sensitivity C-reactive protein (hs-CRP) and progressive cerebral infarction. Methods from January 2014 to March 2016, 136 patients with acute cerebral infarction were selected from Qianxinan people's Hospital of Guizhou Province as study subjects. According to the levels of hs-CRP at admission, 48 hours and 72 hours after onset, the patients were divided into two groups: continuous elevated group and non-persistent elevated group. According to whether progressive cerebral infarction occurred or not, the patients were divided into progressive group and non-progressive group. The baseline data, clinical indexes, neurological deficit score (NHISS), fever and carotid artery stenosis were compared in each group. Logistic regression analysis was used to screen the influencing factors of continuous increase of hs-CRP and progressive cerebral infarction. Results 36.8% (50 / 136) of all patients had progressive cerebral infarction (34.6%) (47 / 136) with continuous increase of hs-CRP. The incidence of continuous elevation of hs-CRP in the progressive group was 54.0% (27 / 50), which was higher than that in the non-progressive group (23.3%) (20 / 86) (P0.05). Multivariate logistic regression analysis showed that diabetes history, triglyceride and white blood cell count were the influencing factors for the continuous increase of hs-CRP in patients (P0.05). Fasting blood glucose (FBG), NHISS score at admission, and constant increase of fever hs-CRP were the influencing factors of progressive cerebral infarction (P0.05). Conclusion the level of hs-CRP in patients with progressive cerebral infarction is higher than that in patients with progressive cerebral infarction.
【作者单位】：贵州省黔西南州人民医院神经内科;
【分类号】：R743.33

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