胼胝体膝部梗死听觉事件相关电位P300的特征及其诊断价值

发布时间：2018-07-07 15:29

本文选题：胼胝体膝部梗死 + 听觉事件相关电位P　；参考：《中国老年学杂志》2017年10期

【摘要】：目的探讨胼胝体膝部梗死患者听觉事件相关电位P300的特征及其在患者诊断中的应用价值。方法选择胼胝体膝部梗死患者17例(病例组)及同期健康检查人群17例(对照组)为研究对象。采用美国Nicolet Spirit脑诱发电位仪,进行听觉事件相关电位P300检测,分析比较病例组与对照组之间P300潜伏期及波幅有无差异(P0.05)。结果病例组P300潜伏期显著长于对照组(t=4.85,P0.05);病例组波幅显著低于对照组(t=8.79,P0.05);病例组简易精神状态检查(MMSE)量表评分与波幅明显负相关性(r=-0.61,P0.05),但与潜伏期无明显相关性(r=-0.07,P=0.78)。以潜伏期为指标,诊断胼胝体膝部梗死的敏感性为94.12%,特异性为76.47%,ROC曲线下面积为0.83;以波幅为参考指标诊断诊断胼胝体膝部梗死的敏感性为100%,特异性为94.22%,ROC曲线下面积为0.98。结论胼胝体膝部梗死患者听觉事件相关电位P300的潜伏期延长和MMSE评分与波幅明显负相关性,可作为电生理诊断的参考指标。
[Abstract]:Objective to investigate the characteristics of auditory event-related potential (P300) in patients with genu infarction of corpus callosum and its diagnostic value. Methods 17 cases of genu infarction of corpus callosum (case group) and 17 cases of health examination (control group) were selected. The auditory event-related potential (P300) was detected by Nicolet Spirit brain evoked potentiometer in the United States of America. The latency and amplitude of P300 were compared between the case group and the control group (P0.05). Results the latency of P300 in the case group was significantly longer than that in the control group (P 0.05), the amplitude of the wave in the case group was significantly lower than that in the control group (t = 8.79 P 0.05), and the score of the MMSE scale in the case group was negatively correlated with the amplitude of the wave (P 0.05), but there was no significant correlation between the amplitude and the latency (r 0. 07 P 0. 78). The sensitivity and specificity for the diagnosis of genu infarction of corpus callosum were 94.12, 76.47 and 0.83 respectively, and the sensitivity and specificity of the ROC curve were 100 and 0.98, respectively, using the amplitude of wave as the reference index for the diagnosis of the genu infarction of corpus callosum. Conclusion the latency of auditory event-related potential P300 in patients with genu infarction of corpus callosum is prolonged, and the MMSE score is negatively correlated with the amplitude of the wave, which can be used as a reference index for the diagnosis of electrophysiology.
【作者单位】：天津市西青医院神经内科;天津医科大学总医院神经内科;
【分类号】：R743.33

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