急性脑梗死伴高血压患者血清中B型脑钠肽、基质金属蛋白酶-2和-9表达

发布时间：2018-07-14 07:30

【摘要】：目的观察急性脑梗死伴高血压患者血清中B型脑钠肽(BNP)、基质金属蛋白酶(MMP)-2和-9的表达,分析其临床意义。方法共纳入94例患者,具有急性脑梗死伴有恶性高血压病史的患者28例作为A组,具有急性脑梗死伴有常规高血压病史的患者47例作为B组,具有急性脑梗死无任何高血压的患者19例作为C组。检测血清中BNP、MMP-2和MMP-9的表达。结果 3组血清中BNP、MMP-2和MMP-9的表达差异有统计学意义。A组和B组血清中BNP、MMP-2和MMP-9的表达与梗死灶的体积密切相关,A组和B组血清中BNP、MMP-2和MMP-9的表达与患者的预后相关。线性相关分析显示A、B组血清中MMP-2和MMP-9的表达呈正相关。结论急性脑梗死伴高血压病史患者血清中BNP、MMP-2和MMP-9的表达升高,三者高表达对病变的形成和进展有一定促进作用。病变形成过程中血清中MMP-2和MMP-9的表达具有正向协同作用。
[Abstract]:Objective to observe the expression of type B brain natriuretic peptide (BNP), matrix metalloproteinase (MMP) -2 and matrix metalloproteinase (MMP) in the serum of patients with acute cerebral infarction with hypertension. Methods A total of 94 patients were included. 28 patients with acute cerebral infarction accompanied with malignant hypertension were treated as group A and 47 patients with acute cerebral infarction with a history of conventional hypertension as group B. There were 19 patients with acute cerebral infarction without any hypertension as group C. The expression of BNPP MMP-2 and MMP-9 in serum was detected. Results the expression of BNPMP-2 and MMP-9 in serum of group A and group B was significantly different. The expression of BNPMP-2 and MMP-9 in serum of group A and group B was closely related to the volume of infarct focus. The expression of BNP-MMP-2 and MMP-9 in serum of group A and group B was correlated with the prognosis of the patients. Linear correlation analysis showed a positive correlation between MMP-2 and MMP-9 expression in serum of group A B. Conclusion the expression of BNP-MMP-2 and MMP-9 in the serum of patients with acute cerebral infarction and hypertension is increased, and the high expression of these three proteins can promote the formation and progression of the disease. The expression of MMP-2 and MMP-9 in serum had positive synergistic effect.
【作者单位】：齐齐哈尔医学院附属三院神经内科;
【基金】：齐齐哈尔市科学技术计划项目(No.SFGG-201207)
【分类号】：R544.1;R743.33

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