前庭性偏头痛神经通路的功能性核磁研究

发布时间：2018-07-15 18:54

【摘要】：目的:探索前庭性偏头痛(VM)患者的异常神经通路,并定位其功能区,以推断其可能的发病机制。方法:对VM组(20例)、无先兆的偏头痛(MwoA)组(20例)和健康对照组(20例)分别进行冷水灌耳试验,选择刺激时以及刺激间歇期的全脑血氧饱和度依赖的功能核磁共振成像(BOLD fMRI),获取VM组、MwoA组及健康对照组的激活区,进行组间对比。结果:所有试验对象冷水灌耳试验后,多处皮层及皮层下区域激活,顶叶、颞叶、岛叶皮质、扣带回、丘脑、尾状核区、视辐射、楔前叶均观察到BOLD信号明显改变。对比发现VM患者的丘脑背内外侧核区正激活,枕颞内侧回皮质负激活(P0.05)。结论:fMRI能较客观清晰地反应脑部各功能区活动情况;VM患者发病机制为丘脑背内外侧区及枕颞内侧回皮质异常激活,在前庭感觉通路传递过程中与痛觉通路产生交叉。
[Abstract]:Aim: to explore the abnormal neural pathways in patients with vestibular migraine (VM) and to locate their functional regions in order to infer the possible pathogenesis. Methods: cold water perfusion test was performed in VM group (20 cases), migraine without aura group (20 cases) and healthy control group (20 cases). Functional magnetic resonance imaging (bod fMRI) was used to obtain activation areas of MwoA group and healthy control group during stimulation and intermittent stimulation. Results: after cold water perfusion in all subjects, the activation of multiple cortical and subcortical regions, the changes of bod signal were observed in parietal lobe, temporal lobe, insular cortex, cingulate gyrus, thalamus, caudate nucleus, visual radiation and prewedge lobe. The positive activation of dorsal and lateral thalamic nucleus and negative activation of medial occipito-temporal cortex were found in VM patients (P0.05). Conclusion in VM patients, the abnormal activation of the medial and dorsal thalamic area and the medial occipito-temporal cortex is the mechanism of abnormal response to the activity of the functional regions of the brain by FMRI, which intersects the nociceptive pathway during the transmission of vestibular sensory pathway.
【作者单位】：天津市环湖医院耳鼻咽喉头颈外科;
【分类号】：R747.2

【相似文献】