天麻素辅助治疗癫痫的对照研究

发布时间：2018-07-20 16:04

【摘要】：研究目的：本文通过临床资料研究，观察天麻素联合卡马西平治疗癫痫的效果研究方法：本课题采用临床调查的研究方法，对2011年3月至2012年9月在十堰市人民医院门诊就诊的癫痫患者及部分住院的癫痫患者，将符合诊断标准的92例患者采用随机均衡方法分为天麻素联合卡马西平治疗组和单用卡马西平治疗的对照组，治疗组在卡马西平治疗的基础上辅以天麻素，对照组患者单纯服用卡马西平，分别统计各组用药后对比用药前的各项临床指标，检测并记录脑电图、发作频率、程度、兼有症状等改善情况以及这些患者治疗前和治疗后的月平均发作次数。结果: 1.临床疗效统计:治疗组总有效率为81%，对照组总有效率为69%。治疗(天麻素组)和对照组比较有显著差异(P0.05) 2.脑电图改变:治疗组在治疗前有32例脑电图异常，通过天麻素辅助治疗改善率为71.87%;对照组改善率为48.00%。两组比较有显著差异P0.05 3.对各类型癫痫患者治疗前后发作时间及频率的比较:治疗组与对照组有显著差异(P0.05)，但是由于此次临床研究的病例数较少，具体差异性仍有待进一步研究推论 4.副反应:此时研究过程中治疗组有少数病人存在口鼻干燥、头昏以及胃不适等症状，但均不致影响病人继续用药，未行特殊处理。对照组有少量病人出现嗜睡反应，经相关对症处理后好转，未影响继续用药结论：天麻素辅助治疗癫痫效果良好，可在一定程度上可减轻癫痫发作程度，改善临床症状。
[Abstract]:Objective: to observe the efficacy of Gastrodin combined with carbamazepine in the treatment of epilepsy. From March 2011 to September 2012, patients with epilepsy and some of the epileptic patients hospitalized in the outpatient clinic of Shiyan Municipal people's Hospital, 92 patients who met the diagnostic criteria were randomly divided into Gastrodin combined with carbamazepine treatment group and control group treated with carbamazepine alone. The treatment group was supplemented with Gastrodin on the basis of carbamazepine treatment. The patients in the control group were treated with carbamazepine alone. The clinical indexes before the treatment were counted, and EEG, frequency and degree of attack were detected and recorded. Symptoms and symptoms were improved and the average number of episodes before and after treatment was reported. Results: 1. The total effective rate was 81 in the treatment group and 69 in the control group. There was a significant difference between the treatment group and the control group (P0.05). EEG changes: before treatment there were 32 cases of abnormal EEG in the treatment group, the improvement rate of Gastrodin adjuvant therapy was 71.87, and the improvement rate of the control group was 48.00%. There was significant difference between the two groups (P0.05). Comparison of seizure time and frequency before and after treatment: there were significant differences between the treatment group and the control group (P0.05), but due to the small number of cases in this clinical study, the specific differences still need to be further studied and inferred. 4. Side effects: a few patients in the treatment group had symptoms such as dry mouth and nose, dizziness and stomach discomfort during the course of the study, but these symptoms did not affect the patients' continued medication without special treatment. In the control group, a small number of patients appeared narcolepsy reaction, after the related symptomatic treatment improved, no influence on the continued use of medicine conclusion: Gastrodin adjuvant treatment of epilepsy is good, can alleviate the degree of epilepsy, improve clinical symptoms to a certain extent.
【学位授予单位】：湖北中医药大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R742.1

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