急性缺血性脑卒中患者血清PTX3水平变化及其与神经功能缺损和近期预后的关系
发布时间：2018-07-21 16:02
【摘要】：目的观察急性缺血性脑卒中患者血清正五聚蛋白3(PTX3)水平变化,并分析其与患者神经功能缺损和近期预后的关系。方法选取急性缺血性脑卒中患者100例为病例组,来院体检的志愿者100例为对照组。分别于入院第1、7、14天检测两组血清PTX3,进行美国国立卫生院神经功能缺损评分(NHISS评分)以评价神经功能缺损情况。对病例组随访3个月,采用改良Rankin量表(mRS)评分评价近期预后,比较不同程度残疾患者血清PTX3水平。分析血清PTX3水平与急性缺血性脑卒中患者NHISS评分、mRS评分的相关性。结果病例组入院第7天血清PTX3水平高于入院第1、14天,且病例组入院第1、7、14天血清PTX3水平均高于对照组(P均0.05)。病例组患者血清PTX3水平与NHISS评分呈正相关关系(r=1.483,P0.01);血清PTX3水平与mRS评分呈正相关关系(r=1.299,P0.01)。随访3个月,病例组残疾30例(mRS评分≥2分,轻度12例、重度8例、中重度6例、重度4例)、非残疾(mRS评分2分)70例,末次随访时残疾亚组血清PTX3水平高于非残疾亚组(P0.01)。入院第7天不同残疾程度患者血清PTX3水平均高于入院第1、14天(P均0.05);入院第7天时重度残疾者、中重度残疾者与中度残疾者血清PTX3水平高于轻度残疾者(P均0.01);重度残疾者入院第1、7、14天血清PTX3水平均高于轻度残疾者(P均0.05)。结论急性缺血性脑卒中患者血清PTX3水平升高,且与NHISS评分、mRS评分均呈正相关关系;血清PTX3水平越高,急性缺血性脑卒中患者的神经功能缺损程度越严重、近期预后越差。
[Abstract]:Objective to observe the changes of serum normal pentagglutinin 3 (PTX3) levels in patients with acute ischemic stroke, and to analyze the relationship between PTX3 levels and neurological deficit and short-term prognosis. Methods 100 patients with acute ischemic stroke were selected as case group and 100 volunteers as control group. Serum PTX3 was measured on the 1st day and 14th day after admission. The neurological deficit score (NHISS) of the National Institutes of Health (NIH) was used to evaluate the neurological impairment. The patients were followed up for 3 months to evaluate the short-term prognosis with modified Rankin scale (Mrs) and to compare the serum PTX3 levels in patients with different degrees of disability. To analyze the correlation between serum PTX3 level and NHISS score and Mrs score in patients with acute ischemic stroke. Results the serum PTX3 level on the 7th day after admission was higher than that on the 1st day of admission, and the serum PTX3 level of the case group was higher than that of the control group on the 1st day of admission (P 0.05). There was a positive correlation between serum PTX3 level and NHISS score (r = 1.483, P 0.01), and a positive correlation between serum PTX3 level and Mrs score (r = 1.299, P 0.01). 30 cases of disability (Mrs score 鈮，
本文编号：2136044
[Abstract]:Objective to observe the changes of serum normal pentagglutinin 3 (PTX3) levels in patients with acute ischemic stroke, and to analyze the relationship between PTX3 levels and neurological deficit and short-term prognosis. Methods 100 patients with acute ischemic stroke were selected as case group and 100 volunteers as control group. Serum PTX3 was measured on the 1st day and 14th day after admission. The neurological deficit score (NHISS) of the National Institutes of Health (NIH) was used to evaluate the neurological impairment. The patients were followed up for 3 months to evaluate the short-term prognosis with modified Rankin scale (Mrs) and to compare the serum PTX3 levels in patients with different degrees of disability. To analyze the correlation between serum PTX3 level and NHISS score and Mrs score in patients with acute ischemic stroke. Results the serum PTX3 level on the 7th day after admission was higher than that on the 1st day of admission, and the serum PTX3 level of the case group was higher than that of the control group on the 1st day of admission (P 0.05). There was a positive correlation between serum PTX3 level and NHISS score (r = 1.483, P 0.01), and a positive correlation between serum PTX3 level and Mrs score (r = 1.299, P 0.01). 30 cases of disability (Mrs score 鈮，
本文编号：2136044
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