帕金森病患者经颅超声黑质高回声与临床特征的关系
发布时间：2018-07-24 10:26
【摘要】：目的探讨帕金森病(Parkinson’s disease,PD)患者经颅超声黑质高回声与临床特征的关系。方法1以2015年10月-2016年10月就诊于河北医科大学第一医院神经内二科的PD患者作为研究对象,共81例,记录基本资料,包括性别、年龄、发病年龄、病程及文化程度。2收集患者的临床特征资料:1)PD家族史、吸烟史和毒物接触史。2)非运动症状:采用问诊的方式收集患者的嗅觉障碍、睡眠障碍(快速眼动相睡眠行为障碍(Rapid eye movement sleep behavior disorder,RBD)和过度日间嗜睡)、自主神经功能障碍(体位性低血压、便秘和排尿障碍),采用汉密尔顿焦虑抑郁量表及蒙特利尔认知评定量表评估患者神经精神障碍(焦虑抑郁情绪和认知功能)。3)运动症状:采用Hoehn-Yahr分期和统一帕金森病量表第三部分评估患者的运动症状。3采用经颅超声(Transcranial sonography,TCS)技术检测PD患者黑质回声的强度、面积及高回声面积/中脑面积(S/M)比值,根据回声强度将患者分为病例组(黑质高回声组)和对照组(黑质正常回声组)。4分析患者黑质高回声和上述临床特征的关系。结果1 73例PD患者(8例因颞窗条件差而未能探测)黑质回声Ⅰ~Ⅴ级的人数分别为0、28、35、8及2例,病例组45例(61.6%),对照组28例(38.4%)。2病例组中31例(68.9%)患者黑质高回声侧位于运动症状严重的对侧,5例(11.1%)患者位于同侧,9例(20.0%)患者双侧黑质回声均增强,黑质高回声的侧别与运动症状重的侧别有显著关联性(P0.01)。3不同黑质回声级别患者的高回声面积和S/M值均具有显著差异(P0.01)。4单因素分析发现吸烟的PD患者出现黑质高回声的危险性低于不吸烟的患者(0R=0.375,P0.05),伴嗅觉障碍的PD患者出现黑质高回声的危险性高于不伴嗅觉障碍的患者(0R=4.531,P0.05),伴RBD的PD患者出现黑质高回声的危险性高于不伴RBD的患者(0R=3.422,P0.05)。5多因素分析发现男性和嗅觉障碍是PD患者出现黑质高回声的危险因素(OR=17.594/8.949,P0.05)。结论1 PD患者黑质高回声侧多位于肢体运动症状较重侧的对侧。2 PD患者黑质回声强度的等级、高回声面积和S/M值均可反映黑质回声强度的情况。3吸烟的PD患者出现黑质高回声的危险性低;男性、伴嗅觉障碍或RBD的PD患者出现黑质高回声的危险性高于女性、不伴嗅觉障碍或RBD的患者。
[Abstract]:Objective to investigate the relationship between transcranial sonographic hyperechogenicity and clinical features in patients with Parkinson's disease (PD). Methods 1 A total of 81 PD patients from October 2015 to October 2016 in the Department of Neurology, first Hospital of Hebei Medical University, were studied. The basic data, including sex, age, age of onset, were recorded. Course of disease and education. 2. Collect the clinical characteristic data of the patient: 1) PD family history, smoking history and toxicant contact history .2) Non-motor symptom: collect the patient's olfactory disorder by means of inquiring. Sleep disorder (Rapid eye movement sleep behavior disorderia) and excessive daytime sleepiness, autonomic dysfunction (postural hypotension), Constipation and dysuria), using the Hamilton anxiety and Depression scale and the Montreal Cognitive rating scale to assess the motor symptoms of neuropsychiatric disorders (anxiety, depression and cognitive function): using Hoehn-Yahr staging and unifying Parkinson's The third part of the scale was used to assess the intensity of substantia nigra echo in PD patients by transcranial ultrasound (TCS). According to the echo intensity, the patients were divided into two groups: the case group (the hyperechoic group) and the control group (the normal echoic group). 4. The relationship between the hyperechoicity of the substantia nigra and the above clinical characteristics was analyzed. Results the number of 鈪，
本文编号：2141080
[Abstract]:Objective to investigate the relationship between transcranial sonographic hyperechogenicity and clinical features in patients with Parkinson's disease (PD). Methods 1 A total of 81 PD patients from October 2015 to October 2016 in the Department of Neurology, first Hospital of Hebei Medical University, were studied. The basic data, including sex, age, age of onset, were recorded. Course of disease and education. 2. Collect the clinical characteristic data of the patient: 1) PD family history, smoking history and toxicant contact history .2) Non-motor symptom: collect the patient's olfactory disorder by means of inquiring. Sleep disorder (Rapid eye movement sleep behavior disorderia) and excessive daytime sleepiness, autonomic dysfunction (postural hypotension), Constipation and dysuria), using the Hamilton anxiety and Depression scale and the Montreal Cognitive rating scale to assess the motor symptoms of neuropsychiatric disorders (anxiety, depression and cognitive function): using Hoehn-Yahr staging and unifying Parkinson's The third part of the scale was used to assess the intensity of substantia nigra echo in PD patients by transcranial ultrasound (TCS). According to the echo intensity, the patients were divided into two groups: the case group (the hyperechoic group) and the control group (the normal echoic group). 4. The relationship between the hyperechoicity of the substantia nigra and the above clinical characteristics was analyzed. Results the number of 鈪，
本文编号：2141080
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