脂蛋白相关磷脂酶A2在老年急性缺血性脑卒中早期诊断中的临床价值

发布时间：2018-07-29 09:45

【摘要】：目的分析脂蛋白相关磷脂酶(Lp-PL)A2在老年急性缺血性脑卒中早期诊断中的临床价值。方法急性缺血性脑卒中患者46例为观察组,同期健康体检者50例为对照组。检测对比两组外周血Lp-PLA2、C-反应蛋白(CRP)、白细胞介素(IL)-10及肿瘤坏死因子(TNF)-α水平,并分析各项指标对急性缺血性脑卒中的早期诊断价值。结果两组外周血IL-10水平无显著性差异(P0.05)。观察组外周血TNF-α、Lp-PLA2及CRP水平均显著高于对照组(P0.05)。观察组外周血指Lp-PLA2与TNF-α(r=0.908,P0.05)及CRP(r=0.819,P0.05)均呈正相关。受试者工作特征(ROC)曲线分析显示,以181.50 ng/ml为截点值,Lp-PLA2诊断急性缺血性脑卒中的敏感性为84.78%,特异性为84.00%,曲线下面积为0.82,优于TNF-α及CRP。结论 Lp-PLA2水平在老年急性缺血性脑卒中患者病程早期即可升高,具有一定辅助诊断价值。
[Abstract]:Objective to analyze the clinical value of lipoprotein associated phospholipase A 2 (Lp-PL A 2) in the early diagnosis of acute ischemic stroke in the elderly. Methods 46 patients with acute ischemic stroke were treated as observation group and 50 healthy persons as control group. The levels of Lp-PLA2C- reactive protein (CRP), (IL)-10 and tumor necrosis factor (TNF)-伪 in peripheral blood of the two groups were detected and compared, and the value of each index in the early diagnosis of acute ischemic stroke was analyzed. Results there was no significant difference in IL-10 level between the two groups (P 0.05). The levels of TNF- 伪 Lp-PLA2 and CRP in the observation group were significantly higher than those in the control group (P0.05). In the observation group, there was a positive correlation between Lp-PLA2 and TNF- 伪 (r = 0.908, P 0.05) and CRP (r = 0.819, P 0.05). The (ROC) curve analysis showed that the sensitivity and specificity of Lp-PLA2 in the diagnosis of acute ischemic stroke with 181.50 ng/ml as the cut-off point were 84.78 and 84.00, and the area under the curve was 0.82which was superior to TNF- 伪 and CRP. Conclusion the level of Lp-PLA2 in aged patients with acute ischemic stroke can be increased at the early stage, and it is valuable in the diagnosis of acute ischemic stroke.
【作者单位】：承德市中心医院神经内科;承德市中心医院神经诊断科;
【基金】：承德市科学技术研究与发展计划项目(No.201422005)
【分类号】：R743.3

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