2015-2016年浙江省义乌市健康人群乙型脑炎抗体水平调查

发布时间：2018-07-31 20:19

【摘要】：目的了解2015-2016年义乌市健康人群乙型脑炎(乙脑)抗体水平。方法随机选取义乌市4个监测点健康人群,分9个年龄组采集血清标本,通过微量细胞中和试验测定乙脑中和抗体。结果在953名调查对象中,乙脑抗体阳性361名,阳性率为37.88%,几何平均滴度(GMT)为1∶9.79。在1岁儿童中,各月龄儿童的抗体阳性率在4.17%(9月龄)-37.93%(0月龄)之间(x2=26.95,P=0.003),GMT在1∶5.23(9月龄)-1∶8.62(0月龄)之间(x2=31.17,P=0.001);在≥1岁人群中,各年龄人群的抗体阳性率在17.57%(7-14岁)-82.69%(35-44岁)之间(x2=73.21,P0.001),GMT在1∶6.43(7-14岁)-1∶22.55(35-44岁)之间(x2=66.77,P0.001)。完成2剂次乙脑减毒活疫苗的140名1-6岁儿童免疫≤1年、1年且≤2年、2年且≤3年、3年后的抗体阳性率和GMT均无显著性差异(x2=2.59,P=0.459;x2=5.47,P=0.140)。结论义乌市全人群中小年龄组儿童的乙脑抗体水平较低,应加强适龄儿童的乙脑疫苗接种工作。
[Abstract]:Objective to investigate the antibody level of Japanese encephalitis (je) in healthy population of Yiwu from 2015 to 2016. Methods healthy people were randomly selected from 4 monitoring sites in Yiwu. Serum samples were collected from 9 age groups, and neutralizing antibody against encephalitis B was determined by microcell neutralization test. Results among 953 subjects, 361 were positive for Japanese encephalitis antibody, the positive rate was 37.888.The geometric mean titer (GMT) was 1: 9.79. In 1-year-old children, the positive rate of antibody was 4.17% (9-month-old) -37.93% (0-month-old) (x22.26.95P0. 003) and the GMT was between 1: 5.23 (9-month-old) -1: 8.62 (0-month-old) (x231.17P0. 001); in people over 1 years old, the GMT was between 1: 5.23 (9 months old) -1: 8.62 (0 month old) (x231.17P0. 001). The positive rate of antibody was 17.57% (7-14 years old) -82.69% (35-44 years old) (x2f73.21 P0.001) and GMT was between 1: 6.43 (7-14 years) -1: 22.55 (35-44 years old). There was no significant difference in antibody positive rate and GMT after 2 doses of live attenuated Japanese encephalitis vaccine in 140 children aged 1-6 years after immunization for 1 year, 1 year and 鈮，

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