累积血压暴露值对脑卒中事件的预测价值

发布时间：2018-08-02 16:19

【摘要】：目的探讨累积血压暴露[累积收缩压(cumSBP)和累积舒张压(cumDBP)]对脑卒中的预测价值。方法采取前瞻性队列研究方法,以参加2006-2007、2008-2009、2010-2011年开滦集团健康体检的无脑卒中病史的职工53 582人为观察对象,以脑卒中发生为终点事件。依据cumSBP(mm Hg·年)和cumDBP(mm Hg·年)四分位分组:cumSBP第1四分位组(480)、cumSBP第2四分位组(480~520)、cumSBP第3四分位组(520~560)、cumSBP第4四分位组(≥560),cumDBP第1四分位组(320)、cumDBP第2四分位组(320~340)、cumDBP第3四分位组(340~360)、cumDBP第4四分位组(≥360)。用寿命表法计算总人群不同cumSBP、cumDBP的累积脑卒中发生率,并采用Cox比例风险模型分析cumSBP、cumDBP第4四分位组对脑卒中事件的影响。结果观察对象53 582人中,男性41 171人(76.8%),女性12 411人(23.2%),年龄(49.0±11.8)岁。随访(2.99±0.40)年,共发生脑卒中事件526例。总人群脑卒中事件累积发生率随着cumSBP、cumDBP的增高而呈上升趋势。多因素Cox比例风险回归模型分析显示,与cumSBP第1四分位组相比,cumSBP第3、4四分位组发生脑卒中事件的HR值(95%CI)分别为1.69(1.21~2.35)、2.03(1.47~2.80);与cumDBP第1四分位组相比,cumDBP第3、4四分位组发生脑卒中事件的HR值(95%CI)分别为1.46(1.07~1.98)、1.86(1.41~2.46)。结论高cumSBP和高cumDBP是发生脑卒中事件的危险因素。
[Abstract]:Objective to investigate the predictive value of cumulative blood pressure exposure [cumulative systolic pressure (cumSBP) and cumulative diastolic pressure (cumDBP)] for cerebral apoplexy. Methods a prospective cohort study was adopted to observe the incidence of stroke in 53582 workers who participated in the medical history of Kailuan Kailuan Group for 2006-20072008-20092010-2011 in the history of apoplexy without stroke. According to cumSBP (mm Hg year) and cumDBP (mm Hg year) four sub division groups: cumSBP first four partition group (480), cumSBP second four partition group (480~520), cumSBP third four bit group (520~560), cumSBP fourth four sub group (560), first four bits group (320) Group (> 360). Use the life table method to calculate the cumulative stroke incidence of cumSBP and cumDBP in the total population, and to analyze the impact of cumSBP and cumDBP fourth four on stroke events by the Cox proportional hazard model. Results among 53582 men, 41171 men (76.8%), 12411 women (23.2%), and age (49 + 11.8) years of age were followed up (2.99 + 0.40). There were 526 cases of stroke events in the year. The cumulative incidence of stroke events in the total population increased with the increase of cumSBP and cumDBP. The multiple factor Cox proportional risk regression model showed that the HR value of stroke events in cumSBP 3,4 four group was 1.69 (1.21~2.35) and 2.03 (1.47~2.), 2.03 (1.47~2.), respectively, and 2.03 (1.47~2.). 80); compared with the cumDBP first four group, the HR value of stroke events in the cumDBP 3,4 four division (95%CI) was 1.46 (1.07~1.98) and 1.86 (1.41~2.46). Conclusion high cumSBP and high cumDBP were the risk factors for the occurrence of stroke events.
【作者单位】：开滦总医院心内科;华北理工大学研究生院;华北理工大学附属医院;
【分类号】：R743.3

【相似文献】