抗血管药物治疗在新诊断胶质母细胞瘤中的网状meta分析

发布时间：2018-08-07 09:47

【摘要】：目的评价在新诊断胶质母细胞瘤患者中不同抗血管药物治疗何种效果最优。方法全面检索Pubmed、Cochrane library、Embase、CBM、CNKI、万方、维普各数据库,按照研究设计进行文献筛选和质量评估,提取数据后采用Stata13.0进行网状meta分析。结果分析揭示在新诊断胶质母细胞瘤患者中不同血管抑制剂加入/不加入标准替莫唑胺方案的治疗效果均优于其单一治疗方案;其中西仑吉肽2000mg/5/week干预效果最优,其次为贝伐单抗结合伊立替康治疗加入Stupp方案、贝伐单抗结合伊立替康方案、贝伐单抗结合Stupp方案、西仑吉肽2000mg/2/week方案。副作用方面揭示:仅西仑吉肽2000mg/2/week方案和BEV方案比Stupp方案的副作用发生率高,差异有统计学意义(P0.05);其他方案与Stupp方案相比副作用发生率均无统计学差异(P0.05)。结论在符合本研究标准的新诊断胶质母细胞瘤患者中不同血管抑制剂的干预效果均优于Stupp方案;然而,当前研究的样本量相对较少,贝伐单抗相关的治疗方案和西仑吉肽相关的治疗方案何种效果更优并不能给予确定的结论。
[Abstract]:Objective to evaluate the best effect of different anti-vascular drugs in newly diagnosed glioblastoma patients. Methods We searched the database of Pubmedus Cochrane libraryary Embase (Stata13.0), Wan-fang (Wan-fang) and Wei-Pu (Wei-Pu). According to the research design, we screened the literature and evaluated the quality of the data. The data were extracted and analyzed by Stata13.0 for reticular meta analysis. Results the results showed that in newly diagnosed glioblastoma patients, the effect of different angiosuppressants added with or without standard temozolidomide regimen was better than that of the single treatment regimen, and the intervention effect of 2000mg/5/week was the best in the patients with newly diagnosed glioblastoma. Secondly, bevacizumab combined with irinotecan was added into Stupp regimen, bevacizumab combined with irinotecan regimen, bevacizumab binding Stupp regimen, and cilunidin 2000mg/2/week regimen. Side effects revealed that: the incidence of side effects of 2000mg/2/week regimen and BEV regimen was higher than that of Stupp regimen (P0.05); there was no significant difference between other schemes and Stupp regimen (P0.05). Conclusion the intervention effect of different vascular inhibitors in newly diagnosed glioblastoma patients who meet the criteria of this study is better than that of Stupp regimen, however, the sample size of the current study is relatively small. The conclusion that bevacizumab-related treatment regimen and cilunidin-related treatment regimen is more effective is not certain.
【作者单位】：华北理工大学附属医院神经外科;河北省沧州市肃宁县人民医院神经外科;华北理工大学附属医院护理部;华北理工大学附属医院重症监护病房;
【分类号】：R739.41

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