丁苯酞联合山楂叶总黄酮治疗老年脑梗死的疗效及对外周血神经元特异性烯醇化酶的影响

发布时间：2018-08-14 19:18

【摘要】：目的:探讨丁苯酞联合山楂叶总黄酮治疗老年脑梗死的疗效及对外周血神经元特异性烯醇化酶(NSE)表达的影响。方法:选取我院在2013年1月至2015年1月期间收治的86例老年脑梗死患者,根据用药不同分为丁苯酞组和联合用药组各43例。丁苯酞组给予丁苯酞软胶囊(恩必普)进行治疗,联合用药组在此基础上加用山楂叶总黄酮进行治疗。结果:治疗后,联合用药组神经功能缺损评分(NIHSS)及临床疗效较丁苯酞组患者改善更为显著,组间比较差异具有统计学意义(分别t=5.148 2,P0.01;χ~2=4.073 7,P0.05);经过治疗后,两组患者总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)等指标均有了不同程度的改善(均P0.01),且联合用药组TG、TC及LDL-C水平的降低更为显著,而HDL-C水平的升高更为显著(分别t=3.128 4、3.524 3、2.043 1、2.223 9,P0.05或P0.01);同时,联合用药组患者大脑中动脉狭窄程度好转情况明显优于丁苯酞组,NSE水平降低也更为显著(分别χ~2=3.902 5,P0.05;t=5.148 2,P0.05)。两组患者均未出现严重的不良反应。结论:丁苯酞联合山楂叶总黄酮治疗中老年脑梗死患者的疗效显著,能够改善患者血脂水平,减轻患者的神经损伤,逆转大脑中动脉狭窄,不良反应轻微,而且能够有效降低NSE蛋白表达水平,能够为患者病情的治疗提供参考,也有助于患者病情的康复效果评估,值得临床推广应用。
[Abstract]:Objective: to investigate the effect of butyphthalide combined with total flavone of Hawthorn leaf on senile cerebral infarction and the expression of neuron-specific enolase (NSE) in peripheral blood. Methods: 86 elderly patients with cerebral infarction admitted in our hospital from January 2013 to January 2015 were divided into two groups: butyphthalide group (n = 43) and combination group (n = 43). Butyphthalide group was treated with butyphthalide soft capsule (Enbizol), and the combination group was treated with Hawthorn leaf flavonoids. Results: after treatment, the neurological deficit score (NIHSS) and the clinical efficacy of the combined treatment group were significantly improved than those of the butyphthalide group, and the difference between the two groups was statistically significant (t = 5.148 2 / P 0.01; 蠂 ~ (2 +) = 4.073 / 7 P 0.05); after treatment, there was no significant difference between the two groups (P > 0.05). Total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were improved in both groups (P0.01). However, the increase of HDL-C level was more significant (t = 3.1284 / 3.524 / 2. 043 1 / 2.223 9), and the improvement of middle cerebral artery stenosis in combination group was significantly better than that of butyphthalide group (蠂 ~ 2 / 2 / 3. 9025 / P 0.05 t 5. 148 2 P 0.05, respectively), and the improvement of middle cerebral artery stenosis in combination group was more significant than that in butyphthalide group (P < 0. 05 or P0. 05). There were no serious adverse reactions in both groups. Conclusion: butyphthalide combined with total flavone of Hawthorn leaves is effective in the treatment of middle and old patients with cerebral infarction. It can improve the level of blood lipid, alleviate the nerve injury, reverse the stenosis of middle cerebral artery, and have slight adverse reactions. Moreover, it can effectively reduce the expression of NSE protein, provide a reference for the treatment of the patient's condition, and also be helpful for the evaluation of the rehabilitation effect of the patient's condition, which is worthy of clinical popularization and application.
【作者单位】：唐山工人医院;
【分类号】：R743.3

【相似文献】