突触相关蛋白102的结构、功能及相关研究进展
发布时间：2018-08-18 17:10
【摘要】：突触相关蛋白102(SAP102)是突触后膜区域中一种重要的支架蛋白,属于膜相关鸟苷酸激酶家族(MAGUK),在新生和成熟的神经元中均有高表达。SAP102有助于特化结构域的受体,如N-甲基-D-天冬氨酸(NMDA)受体和α-氨基-3羟基-5甲基-4异恶唑(AMPA)受体和通道蛋白定位在特定膜区域上,并在囊泡内NMDA受体簇的胞质运输过程中起重要的调节作用。此外,SAP102还可参与调节皮质突触的发育。SAP102的表达或功能异常与多种疾病,如阿尔茨海默病与精神分裂症等的发生发展相关。尽管SAP102与神经系统正常生理功能及某些疾病关系密切,但目前人们对SAP102的认识尚不够充分,我们将对SAP102蛋白的结构、生理功能及与之相关疾病的研究进展进行综述。
[Abstract]:Synapse-associated protein 102 (SAP102) is an important scaffold protein in the postsynaptic membrane region. It belongs to the membrane-related guanylate kinase family (MAGUK) and is highly expressed in both neonatal and mature neurons. SAP102 contributes to specific domain receptors, such as N-methyl-D-aspartate (NMDA) receptors and alpha-amino-3-hydroxy-5-methyl-4-isoxazole (AMPA). Receptors and channel proteins are localized in specific membrane regions and play an important role in regulating the cytoplasmic transport of NMDA receptor clusters in vesicles. In addition, SAP102 may also be involved in regulating the development of cortical synapses. Abnormal expression or function of SAP102 is associated with the development of various diseases, such as Alzheimer's disease and schizophrenia. 02 is closely related to the normal physiological function of the nervous system and some diseases, but the understanding of SAP102 is still insufficient. We will review the structure, physiological function and related diseases of SAP102 protein.
【作者单位】： 首都医科大学;首都医科大学解剖学教研室;
【分类号】：R741
本文编号：2190130
[Abstract]:Synapse-associated protein 102 (SAP102) is an important scaffold protein in the postsynaptic membrane region. It belongs to the membrane-related guanylate kinase family (MAGUK) and is highly expressed in both neonatal and mature neurons. SAP102 contributes to specific domain receptors, such as N-methyl-D-aspartate (NMDA) receptors and alpha-amino-3-hydroxy-5-methyl-4-isoxazole (AMPA). Receptors and channel proteins are localized in specific membrane regions and play an important role in regulating the cytoplasmic transport of NMDA receptor clusters in vesicles. In addition, SAP102 may also be involved in regulating the development of cortical synapses. Abnormal expression or function of SAP102 is associated with the development of various diseases, such as Alzheimer's disease and schizophrenia. 02 is closely related to the normal physiological function of the nervous system and some diseases, but the understanding of SAP102 is still insufficient. We will review the structure, physiological function and related diseases of SAP102 protein.
【作者单位】： 首都医科大学;首都医科大学解剖学教研室;
【分类号】：R741
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