微创清除颅内血肿降低病灶周围组织谷氨酸水平及BBB通透性

发布时间：2018-08-20 14:42

【摘要】：目的探讨微创颅内血肿清除对降低病灶周围脑组织谷氨酸(Glu)水平、血脑屏障(BBB)通透性及脑水肿的影响。方法将30只体质量2.80~3.40kg的家兔制作自发性脑出血(ICH)模型,模型制作成功后,分成对照组(MC组)和微创组(MI组),MI组于造模后6h内通过立体定向仪行微创颅内血肿清除术,于术后1、3、7d提取脑组织,检测血肿周围脑组织Glu水平、BBB通透性及脑含水量,并与对照组进行比较分析。结果 MI组在术后1、3、7d血肿周围脑组织Glu水平、BBB通透性及脑含水量均低于MC组,差异有统计学意义(P0.05)。结论微创技术清除颅内血肿有利于降低血肿周围Glu水平、BBB透性及脑含水量。
[Abstract]:Objective to investigate the effects of minimally invasive removal of intracranial hematoma on the level of glutamate (Glu), the permeability of blood-brain barrier (BBB) and brain edema in perifocal brain tissue. Methods the (ICH) model of spontaneous intracerebral hemorrhage was made in 30 rabbits with body mass 2.80~3.40kg. After the establishment of the model, the model was divided into two groups: the control group (MC group) and the minimally invasive group (MI group). The minimally invasive intracerebral hematoma clearance was performed by stereotactic instrument within 6 hours after the establishment of the model in the control group (MC group) and the minimally invasive group (MI group). Brain tissue was extracted at 1: 3 and 7 days after operation. The permeability and water content of Glu in brain tissue around hematoma were measured and compared with those in control group. Results the level of Glu in the brain tissue around hematoma in MI group was significantly lower than that in MC group on the 1st and 7th day after operation (P0.05). Conclusion minimally invasive removal of intracranial hematoma is beneficial to reduce the permeability and water content of Glu around the hematoma.
【作者单位】：贵州省贵阳市第二人民医院神经内科;贵州医科大学计算机教研室;贵州医科大学神经病学教研室;
【基金】：贵阳市卫生和计划生育委员会科学技术计划项目[(2015)筑卫计科技合同字第074号] 贵州省高血压性颅内出血微创诊疗科技创新人才团队
【分类号】：R743.34

【相似文献】