急性脑梗死患者超敏C反应蛋白表达水平及临床意义研究

发布时间：2018-08-21 09:50

【摘要】：目的探讨急性脑梗死患者超敏C反应蛋白表达水平及临床意义。方法选择2015年1月至2016年1月浙江省台州市立医院收治的急性脑梗死患者60例为试验组。同期收集60例健康成人作为对照组。比较两组研究对象超敏C反应蛋白、白细胞介素(IL)-2、IL-4、IL-10、白细胞(WBC)计数和美国国立卫生院神经功能缺损评分(NIHSS)差异并分析其相关性。结果与对照组比较,试验组患者超敏C反应蛋白、IL-2水平、IL-4水平、WBC计数明显升高(P=0.000)。Pearson线性相关性分析显示急性脑梗死患者超敏C反应蛋白与IL-2、IL-4、WBC计数呈正相关(P0.05)。轻型、中型和重型急性脑梗死患者超敏C反应蛋白水平分别为(3.29±0.37)、(3.71±0.50)、(4.14±0.46)mg/L,比较差异有统计学意义(P=0.000)。多元线性回归分析显示IL-2、IL-4和NIHSS是影响急性脑梗死患者血清超敏C反应蛋白的因素(P0.05)。结论超敏C反应蛋白水平与急性脑梗死患者病情严重度相关。
[Abstract]:Objective to investigate the expression level and clinical significance of hypersensitive C reactive protein in patients with acute cerebral infarction. Methods 60 patients with acute cerebral infarction treated in Taizhou City Hospital of Zhejiang Province from January 2015 to January 2016 were selected as experimental group. At the same time, 60 healthy adults were collected as control group. To compare the difference of high sensitive C-reactive protein, interleukin (IL) -2sil 4 IL-10, white blood cell (WBC) count and neurological impairment score (NIHSS) of the National Institutes of Health (NIH) between the two groups and to analyze the correlation between them. Results compared with the control group, the levels of IL-2 and IL-4 in the experimental group were significantly higher than those in the control group (P0. 000). Pearson linear correlation analysis showed that there was a positive correlation between the hypersensitive C-reactive protein and the WBC count of IL-2 and IL-4 in the patients with acute cerebral infarction (P0.05). The levels of hypersensitive C-reactive protein in mild, moderate and severe acute cerebral infarction patients were (3.29 卤0.37), () 3.71 卤0.50), (4.14 卤0.46) mg / L, respectively (P < 0.01). Multiple linear regression analysis showed that IL-2 IL-4 and NIHSS were the factors affecting serum hypersensitive C-reactive protein in patients with acute cerebral infarction (P0.05). Conclusion the level of high-sensitivity C-reactive protein is correlated with the severity of acute cerebral infarction.
【作者单位】：浙江省台州市立医院神经内科;南昌大学医学院;浙江省台州市中心医院神经内科;
【基金】：2014年浙江省医药卫生一般研究计划(2014KYB312)
【分类号】：R743.33

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