不同亚型帕金森病患者多导睡眠图的临床观察

发布时间：2018-08-23 11:46

【摘要】：目的评价不同亚型原发性帕金森病(PD)患者多导睡眠图(PSG)的变化指标,分析PD患者睡眠障碍的临床特点。方法选取原发性PD患者90例[震颤为主型40例,姿势异常步态障碍(PIGD)为主型50例]以及50名健康对照者,进行全夜PSG监测,并对结果进行比较。结果与震颤为主型相比,PIGD为主型总睡眠时间、卧床时间、睡眠中觉醒次数及睡眠效率明显下降,快速眼动(REM)睡眠时间明显减少,差异有统计学意义(均P0.05);睡眠潜伏期、S1(min)、S1(%)、S2(min)、S2(%)、S3+S4(min)、S3+S4(%)差异无统计学意义(均P0.05)。与对照组相比,震颤为主型总睡眠时间、卧床时间明显下降,差异有统计学意义(均P0.05);睡眠中觉醒次数、睡眠效率、REM睡眠时间、睡眠潜伏期、S1(min)、S1(%)、S2(min)、S2(%)、S3+S4(min)、S3+S4(%),差异无统计学意义(均P0.05)。结合视频监测录像观察,PIGD为主型原发性PD患者70%出现REM睡眠行为障碍(RBD)异常,而震颤为主型原发性PD患者2.5%出现RBD异常。结论 PIGD为主型较震颤为主型原发性PD患者更易出现睡眠障碍及RBD异常表现,可能与PD不同亚型的临床异质性相关。
[Abstract]:Objective to evaluate the changes of polysomnography (PSG) in patients with different subtypes of primary Parkinson's disease (PD) and to analyze the clinical features of sleep disorders in PD patients. Methods Night-night PSG monitoring was performed in 90 patients with primary PD [40 patients with tremor predominant type, 50 patients with postural abnormal gait disorder (PIGD) type] and 50 healthy controls, and the results were compared. Results the total sleep time, bed rest time, arousal times and sleep efficiency were significantly decreased, and the sleep time of REM (REM) was significantly decreased compared with the main type of tremor. There was no significant difference in sleep latency (P 0.05) between S _ 1 (min) and S _ 1 (%), S _ 2 (min) / S _ 2 (%), S _ 3S _ 4 (min) and S _ 3S _ 4 (%) (P 0.05). Compared with the control group, the total sleep time and bed rest time were significantly decreased (P 0.05), while the times of awakening, sleep efficiency and sleep time were significantly decreased (P 0.05), and the sleep latency was significantly higher than that of the control group (P < 0.05), but there was no significant difference between the two groups in sleep latency (%), S 3S 4 (min) S 3 S 4 and S 3 S 4 (%). Combined with video surveillance, 70% of patients with primary PD with PIGD had abnormal (RBD) of sleep behavior disorder, while 2.5% of patients with primary PD with tremor were abnormal with RBD. Conclusion patients with primary PD with PIGD are more likely to have sleep disorders and abnormal RBD than those with primary PD with tremor, which may be related to the clinical heterogeneity of different subtypes of PD.
【作者单位】：新疆医科大学第五附属医院神经内科;新疆民政康复医院妇科;
【分类号】：R742.5

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