铜缺乏性脊髓病的研究进展
发布时间：2018-08-23 20:18
【摘要】：铜缺乏性脊髓病（copper deficiency myelopathy，CDM）是铜缺乏导致的神经系统变性疾病其病变主要累及脊髓侧索后索，周围神经和血液系统，，主要表现为双下肢痉挛性截瘫感觉性共济失调末梢性感觉障碍和贫血粒细胞减少等，类似于维生素B12缺乏引起的亚急性联合变性（subacute combined degeneration，SCD）的临床表现磁共振（Magnetic Resonance Imaging，MRI）约半数可见脊髓后索T2高信号主要的治疗方法为补铜治疗该病自Schleper B于2001年首次报道之后，相关报道陆续增多，国内亦有零星报道我们将该病的病因临床表现影像学及血液学特征和治疗转归等进行总结，以提高临床医师对该病的认识
[Abstract]:Copper deficiency myelopathy (CDM) is a degenerative disorder of the nervous system caused by copper deficiency. Its pathological changes mainly involve the dorsal funiculus of the spinal cord, peripheral nerves and blood system. It is characterized by sensory ataxia, peripheral sensory dysfunction and anemia granulocytopenia in spastic paraplegia of both lower extremities, similar to vitamin B12. About half of the clinical manifestations of subacute combined degeneration (SCD) caused by deficiency can be seen by magnetic resonance imaging (MRI). The main treatment for T2 hyperintense signal in the posterior spinal cord is copper supplementation. Since Schleper B first reported this disease in 2001, the related reports have increased, and there are sporadic reports in China. We summarized the etiology, clinical manifestations, hematological features and treatment outcome of the disease in order to improve the understanding of clinicians.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R744
本文编号：2199809
[Abstract]:Copper deficiency myelopathy (CDM) is a degenerative disorder of the nervous system caused by copper deficiency. Its pathological changes mainly involve the dorsal funiculus of the spinal cord, peripheral nerves and blood system. It is characterized by sensory ataxia, peripheral sensory dysfunction and anemia granulocytopenia in spastic paraplegia of both lower extremities, similar to vitamin B12. About half of the clinical manifestations of subacute combined degeneration (SCD) caused by deficiency can be seen by magnetic resonance imaging (MRI). The main treatment for T2 hyperintense signal in the posterior spinal cord is copper supplementation. Since Schleper B first reported this disease in 2001, the related reports have increased, and there are sporadic reports in China. We summarized the etiology, clinical manifestations, hematological features and treatment outcome of the disease in order to improve the understanding of clinicians.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R744
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相关期刊论文 前3条
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本文编号：2199809
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