血清神经元特异性烯醇化酶检测在急性脑梗死患者脑损伤程度评估中的应用

发布时间：2018-08-24 14:00

【摘要】：选取发病72小时内的急性脑梗死患者70例设为试验组,并根据影像学检查所显示的梗死病灶将其分为大面积梗死组32例和中等以下面积梗死组38例。另选我院行健康体检者36例为对照组,采用电化学发光法检测各组人员血清NSE水平。结果大面积梗死组血清NSE水平显著高于中等以下面积梗死组以及对照组(P0.05),中等以下面积脑梗死组血清NSE水平与对照组无显著差异(P0.05)。血清NSE水平与美国国立卫生研究院神经功能缺损(NHISS)评分呈正相关关系,重型组患者NSE水平较中型、轻型及对照组均明显增高,中型组较轻型组及对照组NSE水平增高,差异均有统计学意义(P0.05);轻型组NSE水平较对照组轻度增高,差异无统计学意义(P0.05)。急性脑梗死患者血清NSE水平可为梗死病灶情况及脑损伤程度评估给出客观血清学指标。
[Abstract]:Seventy patients with acute cerebral infarction within 72 hours were selected as experimental group, and were divided into two groups: large infarction group (n = 32) and moderate infarction group (n = 38). The serum NSE levels were measured by electrochemiluminescence (ECL) in 36 healthy subjects as control group. Results the level of serum NSE in large area infarction group was significantly higher than that in lower moderate area infarction group and control group (P0.05). There was no significant difference in serum NSE level between large area cerebral infarction group and control group (P0.05). The level of serum NSE was positively correlated with the (NHISS) score of neurological impairment in the National Institutes of Health. The level of NSE in the severe group was significantly higher than that in the mild group and the control group, and the NSE level in the moderate group was higher than that in the mild group and the control group. The difference was statistically significant (P0.05), and the level of NSE in light group was slightly higher than that in control group (P0.05). The level of serum NSE in patients with acute cerebral infarction can be used as an objective serological index for the assessment of infarct lesion and degree of brain injury.
【作者单位】：重庆市长寿区人民医院;
【分类号】：R743.3

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