氟伐他汀对SAH患者sICAM-1、hs-CRP的影响研究

发布时间：2018-08-26 17:19

【摘要】：目的研究氟伐他汀对蛛网膜下腔出血(SAH)患者血清细胞间黏附分子-1(s ICAM-1)、高敏C反应蛋白(hs-CRP)的浓度变化的影响。方法 60例临床确诊的SAH患者随机分为氟伐他汀组和对照组,氟伐他汀组在常规治疗基础上加用氟伐他汀40 mg,每晚一次口服;对照组仅给予同样的常规治疗。于起病24 h、第3天、第7天、第14天分别检测两组患者s ICAM-1、hs-CRP的含量。两组以SAH病程第14天末或者死亡为本研究终点。采用SPSS 15.0统计软件进行统计学分析,数据以均数±标准差表示,组间比较进行卡方或秩和检验,以P0.05作为差异显著性指标。结果氟伐他汀组患者s ICAM-1水平呈逐渐降低趋势,而对照组第3天、第7天的s ICAM-1水平均呈较前次升高,直至第14天出现降低。氟伐他汀组第3天、第7天、第14天测得的s ICAM-1水平均显著低于对照组(P0.05)。氟伐他汀组血清hs-CRP水平呈逐渐降低趋势,第7天和第14天测得的血清hs-CRP水平均显著低于对照组患者(P0.05)。结论氟伐他汀能有效降低SAH患者血清ICAM-1和hs-CRP的含量水平。
[Abstract]:Objective To study the effect of fluvastatin on serum levels of intercellular adhesion molecule-1 (s ICAM-1) and high-sensitivity C-reactive protein (hs-CRP) in patients with subarachnoid hemorrhage (SAH). The contents of s ICAM-1 and H s-CRP were measured on the 24th, 3rd, 7th and 14th day of onset respectively. The end of 14th day or death of SAH was the end point of the study. SPSS 15.0 statistical software was used for statistical analysis. The data were expressed as mean (+) standard deviation and compared between groups. Results The level of s ICAM-1 in fluvastatin group decreased gradually, while the level of s ICAM-1 in control group increased on day 3 and 7 until day 14. The level of s ICAM-1 in fluvastatin group decreased significantly on day 3, 7 and 14. The levels of serum hs-CRP in fluvastatin group were gradually decreased, and the levels of serum hs-CRP on the 7th and 14th days were significantly lower than those in control group (P 0.05). Conclusion Fluvastatin can effectively reduce the levels of serum ICAM-1 and hs-CRP in SAH patients.
【作者单位】：江西省人民医院神经内科;江西省神经病学研究所;
【分类号】：R743.35

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