豆纹动脉区分支动脉粥样硬化病和腔隙性脑梗死早期神经恶化的临床研究
发布时间：2018-08-30 20:40
【摘要】：目的:探讨豆纹动脉区(LSA)分支动脉粥样硬化疾病(BAD)和腔隙性脑梗死(LI)早期神经恶化(END)危险因素及预后。方法:收集2013年03月至2016年10月期间住院,经头颅MRI检查证实存在LSA急性脑梗死患者76例。按头颅MRI结果分为BAD组(40例),LI组(36例)。入院72 h内根据美国国立卫生研究院卒中量表(NIHSS)评分变化划分为END组(28例),非END组(48例)。收集基线资料、临床资料,进行比较。结果:(1)BAD组糖尿病史、HbA1C、Hcy、入院时NIHSS、偏瘫发生率、发病1个月mRS评分均显著高于LI组;(2)发病3个月mRS评分BAD组与LI组之间无显著性差异;(3)BAD组与LI组比较更易发生END;(4)BAD组中END患者糖尿病史、HbA1C、Hcy、入院时NIHSS、发病1个月mRS评分均高于非END患者;(5)多因素Logistic回归分析示HbA1C、Hcy是BAD组END的危险因素。结论:LSA供血区BAD患者病情重,易进展,HbA1C、Hcy是END的危险因素;BAD组及LI组患者3个月预后均较好。
[Abstract]:Objective: to investigate the risk factors and prognosis of early nerve deterioration (END) in patients with (LSA) branch atherosclerosis and lacunar cerebral infarction (LI). Methods: from March 2013 to October 2016, 76 patients with acute cerebral infarction of LSA were confirmed by cranial MRI examination. According to the results of cranial MRI, the patients were divided into BAD group (40 cases) and Li group (36 cases). Within 72 hours of admission, the patients were divided into END group (28 cases) and non-END group (48 cases) according to the changes of (NIHSS) score of stroke scale of the National Institutes of Health. The baseline data and clinical data were collected and compared. Results: (1) in BAD group, the history of diabetes mellitus and the incidence of NIHSS, hemiplegia were observed. (2) there was no significant difference in mRS score between BAD group and LI group at 3 months after onset, (3) END; (4) BAD group and LI group were more likely to develop HbA1CU HcyA in END group, and mRS evaluation on NIHSS, 1 month after hospitalization in END; (4) BAD group was more likely to occur in END; (4) BAD group than in END; (4) BAD group. (5) multivariate Logistic regression analysis showed that HbA1C,Hcy was the risk factor of END in BAD group. Conclusion the patients with BAD in the blood supply area of W1 LSA are in a serious condition, and HbA1C- Hcy is a risk factor for END. The prognosis of patients in bad group and LI group is better than that in LI group in 3 months.
【作者单位】： 江苏省连云港市第二人民医院神经内科;
【基金】：连云港市“科教兴卫工程”青年科技项目(QN1408)
【分类号】：R743.33
本文编号：2214229
[Abstract]:Objective: to investigate the risk factors and prognosis of early nerve deterioration (END) in patients with (LSA) branch atherosclerosis and lacunar cerebral infarction (LI). Methods: from March 2013 to October 2016, 76 patients with acute cerebral infarction of LSA were confirmed by cranial MRI examination. According to the results of cranial MRI, the patients were divided into BAD group (40 cases) and Li group (36 cases). Within 72 hours of admission, the patients were divided into END group (28 cases) and non-END group (48 cases) according to the changes of (NIHSS) score of stroke scale of the National Institutes of Health. The baseline data and clinical data were collected and compared. Results: (1) in BAD group, the history of diabetes mellitus and the incidence of NIHSS, hemiplegia were observed. (2) there was no significant difference in mRS score between BAD group and LI group at 3 months after onset, (3) END; (4) BAD group and LI group were more likely to develop HbA1CU HcyA in END group, and mRS evaluation on NIHSS, 1 month after hospitalization in END; (4) BAD group was more likely to occur in END; (4) BAD group than in END; (4) BAD group. (5) multivariate Logistic regression analysis showed that HbA1C,Hcy was the risk factor of END in BAD group. Conclusion the patients with BAD in the blood supply area of W1 LSA are in a serious condition, and HbA1C- Hcy is a risk factor for END. The prognosis of patients in bad group and LI group is better than that in LI group in 3 months.
【作者单位】： 江苏省连云港市第二人民医院神经内科;
【基金】：连云港市“科教兴卫工程”青年科技项目(QN1408)
【分类号】：R743.33
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