经典三叉神经痛患者静息态脑功能局部一致性研究
发布时间：2018-08-31 10:55
【摘要】：目的:采用静息态fMRI对经典三叉神经痛(CTN)患者的自发脑功能活动情况进行研究,探究其局部一致性(ReHo)异常的脑区及其异常脑区的自发活动与个体病程和疼痛强度之间的关系,为进一步了解CTN的中枢发病机制提供影像学新证据。研究方法:对25例CTN患者和25名健康对照者进行静息态下脑功能磁共振数据采集;利用DPARSFA软件对影像数据行ReHo分析,然后用dpabi统计模块对病例组及对照组的ReHo值进行两样本t检验;对组间差异脑区ReHo值分别与患者的视觉模拟评分(VAS)和病程行相关分析。结果:与正常对照组相比,CTN患者ReHo值显著减低的脑区包括右侧脑干、右侧额下回、左侧丘脑、左侧颞下回/梭状回和左侧边缘叶/海马旁回;患者ReHo值显著升高的脑区包括左侧中央后回、左侧前扣带回、左侧顶下小叶和右侧枕叶/楔叶/矩状裂周围皮层。右侧脑干显著减低的ReHo值与VAS呈正相关;余组间差异脑区与VAS和病程均未发现相关性。结论:CTN患者存在疼痛相关的功能脑区局部一致性活动的异常,这些脑区与疼痛处理和运动功能有关。这将有助于对CTN病理生理机制的理解。
[Abstract]:Objective: to study the spontaneous brain function in patients with classical trigeminal neuralgia (CTN) by resting fMRI, and to explore the relationship between the spontaneous activity of the brain region with local consistent (ReHo) abnormality and its abnormal brain area and the individual course of disease and the intensity of pain. To provide new imaging evidence for further understanding the central pathogenesis of CTN. Methods: 25 patients with CTN and 25 healthy controls were collected by resting functional magnetic resonance imaging (fMRI), and ReHo was used to analyze the image data with DPARSFA software. Then dpabi statistical module was used to carry out two samples t test on ReHo value of case group and control group, and correlation analysis was made between ReHo value of different brain area and visual analogue score (VAS) and course of disease. Results: compared with the control group, the areas of ReHo decreased significantly in patients with CTN included right brainstem, right inferior frontal gyrus, left thalamus, left infratemporal / fusiform gyrus and left marginal lobe / pariprahippocampal gyrus. Patients with significantly increased ReHo included left posterior central gyrus, left anterior cingulate gyrus, left inferior parietal lobule and right occipital / cuneiform / parietal cortex. There was a positive correlation between the ReHo value of the right brain stem and VAS, and there was no correlation between the difference of brain area and VAS and the course of disease in the other groups. Conclusion there is abnormal local consistent activity in functional brain regions related to pain in patients with 1: CTN. These areas are related to pain management and motor function. This will contribute to understanding the pathophysiological mechanism of CTN.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R445.2;R745.11
本文编号：2214768
[Abstract]:Objective: to study the spontaneous brain function in patients with classical trigeminal neuralgia (CTN) by resting fMRI, and to explore the relationship between the spontaneous activity of the brain region with local consistent (ReHo) abnormality and its abnormal brain area and the individual course of disease and the intensity of pain. To provide new imaging evidence for further understanding the central pathogenesis of CTN. Methods: 25 patients with CTN and 25 healthy controls were collected by resting functional magnetic resonance imaging (fMRI), and ReHo was used to analyze the image data with DPARSFA software. Then dpabi statistical module was used to carry out two samples t test on ReHo value of case group and control group, and correlation analysis was made between ReHo value of different brain area and visual analogue score (VAS) and course of disease. Results: compared with the control group, the areas of ReHo decreased significantly in patients with CTN included right brainstem, right inferior frontal gyrus, left thalamus, left infratemporal / fusiform gyrus and left marginal lobe / pariprahippocampal gyrus. Patients with significantly increased ReHo included left posterior central gyrus, left anterior cingulate gyrus, left inferior parietal lobule and right occipital / cuneiform / parietal cortex. There was a positive correlation between the ReHo value of the right brain stem and VAS, and there was no correlation between the difference of brain area and VAS and the course of disease in the other groups. Conclusion there is abnormal local consistent activity in functional brain regions related to pain in patients with 1: CTN. These areas are related to pain management and motor function. This will contribute to understanding the pathophysiological mechanism of CTN.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R445.2;R745.11
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